Correlation Between CRP And EGFR Gene Mutation In Non-small Cell Lung Cancer

Objective:To investigate the relationship between EGFR gene mutation and serum C-reactive protein(C-reactive protein,CRP)and clinical pathological features in patients with non-small cell lung cancer(Non-small cell lung cancer,NSCLC),and to analyze the predictive value of serum CRP for EGFR gene mutation.Methods:A total of 163 patients who were enrolled in the Second People's Hospital of Yueyang City from January 2016 to October 2018,and were diagnosed as non-small cell lung cancer by histopathology.Tumor tissue samples were obtained by underwent surgery and CT-guided percutaneous lung biopsy(Percutaneous transthoracic needle biopsy,PTNB)or bronchoscopic biopsy,and the EGFR gene was detected and the EGFR gene detection results were collected.Extract the patient's case data(including age,gender,smoking history,histopathological typing and presence or absence of distant metastasis,pre-treatment serum CRP levels,EGFR mutations,etc.)and use the Microsoft Excel 2010 software to establish the database for statistical analysis.Telephone follow-up of the patient or his family members,inquire about the patient's disease diagnosis time and survival status.All the statistical data were input into SPSS22.0 analysis software,and the correlation between EGFR gene mutation and clinicopathological features was analyzed by?~2 test.The ROC curve was used to evaluate the predictive value of age and CRP value for EGFR gene mutation,and the ROC curve was calculated.Lower area(AUC),95%approximate reference confidence interval(95%CI);use Kaplan-Meier method to calculate the survival of patients and plot survival function curve,using Cox single factor regression analysis model and Cox multi-factor regression analysis model The effects of various factors on survival were analyzed separately,and the difference was statistically significant at P<0.05.Results:(1)The mutation rate of EGFR gene was 41.1%(67/163),and exon 19 and 21 were the main mutations,accounting for 49.25%(33/67)and 37.31%(25/67),respectively.(2)There was no correlation between EGFR mutation and serum CRP level(?~2=2.183,P=0.204).(3)The EGFR mutation rate was related to the patient's gender(?~2=10.420,P=0.002),smoking status(?~2=4.605,P=0.042),pathological type(?~2=7.918,P=0.008),and the age of the patient(?~2=0.580,P=0.594),whether there is a distant transfer(?~2=2.556,P=0.150)has nothing to do.(4)The median survival time(20.07 months)of EGFR mutation-positive patients was longer than that of EGFR-negative patients(13.65months),and the median survival time(40 months)of patients with EGFR exon 19 deletion was longer than that of 21 exon mutations(20.56Months),but none of them were statistically significant(P>0.05).(5)Gender has an impact on patient survival.The risk of death in female patients is 0.487 times the risk of death in male patients(95%CI of RR is 0.391-0.851);serum CRP has an impact on patient survival,and the risk of death in patients with high CRP levels It is 1.396 times the low level group(95%CI of RR is 1.374-7.081).Conclusion:(1)The rate of EGFR mutation in non-small cell lung cancer is related to the gender,smoking,and adenocarcinoma.(2)Low levels of CRP in women and serum are associated with better prognosis in patients with NSCLC.(3)Serum CRP level is not be sufficient as an indicator of EGFR gene mutations.