Clinical Observation On Blood Glucose Fluctuation Of Type 2 Diabete Mellitus With Wet And Hot Mutual Syndrome By Qingre Huashi Recipe

Objective:On the basis of insulin therapy,patients with type 2 diabetes mellitus with wet and hot mutual syndrome were given oral antipyretic dampness to observe fasting blood glucose,postprandial blood glucose and blood glucose fluctuation index,and their efficacy and safety were evaluated.Methods:In this study,62 cases of type 2 diabetes mellitus with dampness-heat syndrome were randomly divided into treatment group(n = 31)and control group(n = 31).On the basis of lifestyle intervention,insulin therapy was given to the control group.The treatment group took Qingre Huashi recipe orally on the basis of the control group,observed and recorded the changes of TCM symptoms,blood sugar value,blood glucose fluctuation index(SDBG,PPGE,LAGE)before and after treatment.Statistical software SPSS20.0 was used for statistical analysis of the related data.To evaluate the effectiveness and safety of Qingre Huashi recipe by comparing the indexes before and after treatment in each group and after treatment between the two groups.Results:1.After treatment the total points of TCM syndromes in the treatment group and the control group were improved compared with those before treatment,there were significant statistical differences(P<0.01);there were significant statistical differences between the two groups after treatment(P<0.01),and the total points of TCM symptoms in the treatment group were significantly better than those in the control group.There was a significant statistical difference between the two groups in the individual symptom integral group,and the comparison between the two groups after treatment,the treatment group in abdominal distension,thirst do not want to drink,head and body difficulty,fatigue,urination yellow red,stool discomfort improvement degree is better than the control group,the treatment group is better than the control group in the aspects of abdominal distension,thirst and thirst.There was no significant difference in the score of cardiothoracic boredom(P > 0.05).2.Compared with the curative effect of TCM syndromes in the two groups,the effective rates of the treatment group and the control group were 87.10% and 56.67%respectively,and the overall curative effect of TCM syndromes after treatment was shown by rank and test analysis: Z=-2.467,P=0.014<0.05,the difference was statistically significant.3.After 28 days of treatment,fasting blood glucose and 2h postprandial blood glucose were statistically analyzed in two groups of patients,and there were statistical differences in p<0.05.4.There were significant differences in blood glucose fluctuation between the two groups(P < 0.05).5.Hypoglycemia occurred in 2 patients in the treatment group and 5 patients in the control group.There was no significant difference in the incidence of hypoglycemia between the two groups(P > 0.05).6.There were no two sets of obvious safety index anomalies in the whole process of this study.Conclusion : Qingre Huashi recipe combined with insulin can effectively reduce blood glucose,reduce the fluctuation of blood glucose,reduce the occurrence of hypoglycemia,improve the clinical symptoms of traditional Chinese medicine,there are no serious adverse events in clinical trials,which is worthy of further application and verification in clinical practice.