Exploration Of The Relationship Between Atopic Dermatitis,food Allergy In Infants And Allergic March In Hunan

Objective To explore the relationship between AD,food allergy in infants and allergic march in Hunan by prospective cohort method to further understand the pathogenetic regularity of allergic diseases.MethodsThe subjects were divided into four groups: IgE-mediated food allergy atopic dermatitis group in 92 cases,non-food allergic atopic dermatitis group in 90 cases,infant gastrointestinal food allergy group in79 cases,and normal children group in 100 cases.when All babies saw the doctors in our hospital from February 2015 to February 2016,and The doctors filled out the patient’s data survey forms in detail.All groups of infants were followed up regularly by the telephone,QQ,WeChat,etc.in the first,second and third year after the visit.and inquired of AD,respiratory allergies such as allergic rhinitis,asthma occurrence and development in detail,and finally the data in the follow-up of four groups of patients were analyzed by SPSS25.0.Results(1)The positive rate of family allergy history in IgE-mediated food allergy atopic dermatitis group and non-food allergic atopic dermatitisgroup was higher than that infant gastrointestinal food allergy group(P<0.05).There was no significant difference in the positive rate of family allergy history between IgE-mediated food allergy atopic dermatitis group and non-food allergic atopic dermatitis group(P>0.05).(2)The number of eosinophils in peripheral blood of food allergic AD group,non-food allergic AD group and infant gastrointestinal food allergy group was higher than that of normal children group(P<0.05).(3)The incidence of AD,asthma,allergic rhinitis in food allergic AD group was higher than that in normal children group during 3 years follow-up(P<0.05).(4)The persistent incidence of AD in non-food allergic AD group was higher than that in normal children group,the incidence of asthma was not different between the two groups,and the incidence of allergic rhinitis was not different between the two groups in the first year and the second year after the visit.In the third year,the incidence of non-food allergic AD group was higher than that of normal children group(P<0.05).(5)The incidence of three kinds of atopic diseases in AD group was significantly higher than that in normal children group(P<0.05).(6)The incidence of allergic rhinitis in IgE-mediated food allergy atopic dermatitis group was not different from that in non-food allergic AD group in the first year,and the incidence of persistent AD and asthma in the other 3 years after the visit and allergic rhinitis in the second andthird year was higher than that in the non-food allergic AD group.(7)There was no difference in the incidence of AD,allergic rhinitis and asthma between the infant gastrointestinal food allergy group and normal children group.Conclusion(1)Infant asthma and allergic rhinitis are related to infant atopic dermatitis,which is the first step in allergic march.(2)Infant asthma and allergic rhinitis are related to IgE mediated food allergy in infants.(3)Atopic dermatitis,asthma and allergic rhinitis in infants were not related to non-IgE mediated gastrointestinal food allergy,suggesting that gastrointestinal food allergy in infants may not be involved in allergic march.