| Objective:Through clinical grouping trial,the safety and efficacy of Banxia Xiexin decoction combined with quadruple therapy in clinical practice of Hp positive spleen and stomach dampness-heat syndrome were compared,and its eradication rate in Hp and clinical symptoms of patients were observed.Adverse drug reactions and other aspects of the treatment.Methods:All the cases were from August 2017 to December 2018,with a total of 100 cases.The patients were randomly divided into treatment group(n = 50)and control group(n = 50).The treatment group was given Banxia Xiexin decoction,14 days as a course of treatment and 7 days as a course of treatment combined with quadruple therapy.The control group was treated with quadruple therapy for 14 days as a course of treatment.13C-urea breath test was reexamined 1 month after withdrawal.The eradication rate of Hp,the improvement of TCM symptoms and the adverse reactions were observed.SPSS20.0statistical software is used to analyze the data,and finally the conclusion is drawn.Results:(1)The Hp eradication rate of the two groups was 94% in the treatment group and84% in the control group(P > 0.05).There was no significant difference between the two groups.(2)The total effective rate of TCM symptom score was 94%,78%,P < 0.05,the difference was statistically significant.From the analysis of single symptoms of traditional Chinese medicine,it was found that there were three items(P < 0.05),such as full epigastric ruffiti,pain in upper abdomen,bitter mouth and dry mouth,peculiar smell and acid ingestion in mouth and secondary symptoms,severe limb depression,nausea and vomiting,P < 0.05,and there was significant difference between the two groups(P < 0.05).Among them,anorexia and urination yellow,P > 0.05,the difference was not statistically significant.(3)According to the single symptom analysis of traditional Chinese medicine,the three items of "belching acid" and "limb difficulty" and "urinal yellow" of the main and secondary symptoms were compared between the two groups(P < 0.05),which indicated that the treatment group was better than the control group.Among them,"anorexia" and "nausea and vomiting" were compared between the two groups(P > 0.05),and there wasno significant difference between the two groups,indicating that there was no difference between the two groups in the treatment of these two TCM symptoms.(4)Four adverse events occurred in this study,and one patient in the treatment group had diarrhea;There were 3 cases in the control group,including 1 case of dizziness,1 case of nausea and 1 case of abdominal pain.The above patients had no effect on the results of the trial because the drug side effects were relatively mild and did not meet the criteria for shedding.Conclusion:(1)Compared with the control group,the eradication rate of Hp in the treatment group was higher than that in the control group,and there was no significant difference in the data analysis,which indicated that the two groups were effective in the treatment of spleen and stomach dampness and heat syndrome caused by HP infection.However,the treatment group has some advantages in the improvement of the overall symptoms of traditional Chinese medicine,and can be extended to clinical practice.(2)Compared with quadruple therapy alone,the overall curative effect of TCM syndrome and single symptom(upper abdominal distension,upper abdominal pain,dry mouth and mouth bitterness,peculiar smell in mouth,belching and acid swallowing,severe limb distress,nausea and vomiting)were more significant in patients with spleen and stomach dampness and heat syndrome than those in patients with spleen and stomach dampness and heat syndrome alone.(3)There was no significant difference in the adverse reactions between the two groups,which indicated that the two groups were effective,safe and effective in the treatment of spleen and stomach dampness-heat syndrome caused by HP infection. |
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