| Objective:Observing the clinical curative effect of Ningxin Dingji Capsule in the treatment of patients with persistent atrial fibrillation and qi stagnation and blood stasis syndrome,can offer the effective and safe evidence-based medical testimony to Ningxin Dingji Capsule in the treatment of atrial fibrillation,and expand the clinical application range of Ningxin Dingji Capsule,at the same time,provide effective clinical new ideas and practical experience for the prevention and treatment of atrial fibrillation with integrated Chinese and Western medicine.Methods:selected 66 patients who persistent atrial fibrillation and qi stagnation and blood stasis syndrome from the Department of Cardiology of Shanxi Provincial Institute of Traditional Chinese Medicine and the inpatient department.The treatment group and the control group were selected by statistical random number table method,33 cases each group.There were no significant differences in basic data such as gender,age,duration of illness,and comorbidities.The control group was given metoprolol succinate sustained-release tablets,and the treatment group was treated with metoprolol succinate sustained-release tablets combined with Ningxin Dingji Capsule.After 4 weeks of treatment,the changes of TCM symptoms,atrial fibrillation symptoms,dynamic electrocardiogram,left atrial diameter and other related indicators were observed in the two groups,and the clinical efficacy and safety of Ningxin Dingji Capsule were determined.Results:(1)TCM syndrome total score and efficacy:There was no obvious difference in the single symptom of TCM,physical signs,total symptom scores and total syndrome integral between the two groups before treatment(P>0.05).After treatment,the single symptoms of TCM of palpitation,chest tightness,chest pain and chest rib swelling in the treatment group were better than those in the control group(P < 0.05).Shortness of breath and fatigue symptoms were compared(P>0.05),Ningxin Dingji Capsule can not be considered effective for shortness of breath and fatigue.The symptom scores were compared(P<0.05).The treatment group was better than the control group.The total effective rate of the treatment group and the control group was 91% and 70%,respectively.The treatment group could obviously treatment the TCM syndrome compared with the control group((P<0.05).(2)Symptoms of atrial fibrillation: There was no distinct difference in the symptoms of atrial fibrillation between the two groups before treatment(P>0.05).There was evident difference between the two groups after treatment(P<0.05),which was statistically significant.The treatment group could effectively improve the Symptoms of atrial fibrillation.(3)Dynamic electrocardiogram(ECG): There was no obvious difference in themean ventricular rate between the treatment group and the control group before treatment(P>0.05).After treatment,the treatment group and the control group were compared with the mean ventricular rate before and after treatment(P<0.05),and both of the mean ventricular rate were reduced.The difference was significant between with the control group and the treatment group(P<0.05),and the average ventricular rate control was significantly better in the treatment group than in the control group.In the efficacy of ECG,the total effective rate was 79% in the treatment group and 70% in the control group.Compared with the two groups(P>0.05),the treatment group was equivalent to the control group in terms of total effective rate.(4)Echocardiography: Before treatment,the left atrial diameter of the treatment group and the control group were compared(P>0.05),the difference was not statistically sense.After the treatment,the treatment group was not statistically significant compared with the control group(P>0.05).The treatment group and the control group were equally effective for the left atrial diameter.(5)Coagulation function: Before treatment,there was no statistically significant difference in INR between the two groups(P > 0.05).After treatment,the treatment group was compared(P<0.05),the difference was statistically significant.the control group was compared(P> 0.05),the difference was not statistically significant.the treatment group and the control group was compared(P>0.05),There was no difference,indicating that Ningxin Dingji Capsule did not affect blood coagulation function,did not increase the risk of bleeding,and did not interact with warfarin.Conclusion:Ningxin Dingji Capsule has the effects of promoting qi circulation and relieving pain,activating blood circulation and removing blood stasis,calming heart and tranquilizing mind in the treatment of persistent atrial fibrillation with Qi stagnation and blood stasis syndrome.It can effectively improve the symptoms of traditional Chinese medicine and atrial fibrillation,significantly reduce the average ventricular rate of patients,and has no obvious adverse reactions.Its safety is guaranteed,and more options for clinical treatment of atrial fibrillation. |
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