| Objective:The purpose of us is to observe the clinical curative effect of patients with heart blood stasis syndrome in paroxysmal atrial fibrillation with Mi Gao capsule combine with amiodarone by comparing the treatment group with the control group about p-wave dispersion,p-wave maximum Duration,left atrial diameter,changes in symptom score of TCM and clinical efficacy before and after treatment.And to expo-und the mechanism and analyze the effect of the treatment about appling MiGao capsule to cure heart blood stasis syndrome of paroxysmal atrial fibrillation.Finally to provide guidance of prevention and treatment about integrated traditional and Western medicine.Methods:To choose 45 patients outpatient and inpatient which conform to the diagnosis standard of heart blood stasis syndrome of paroxysmal atrial fibrillation and divide into treatment group for 23 cases and control group for 22 cases randomly.Treatment group is given Mi Gao capsule and amiodarone while the control group is only given amiodarone and the treatment of both groups is 8 weeks.After the treatment,by observing and comparing the changes about Pd,Pmax and LAD’s in electrocardiogram and TCM symptom score in both groups,we could achieve a comprehensive evaluation of clinical curative effect about appling MiGao capsule to cure heart blood stasis syndrome of paroxysmal atrial fibrillation.Results:1.Pd:Before the treatment,Pd of the patients in treatment group was(40.17±5.82ms),while the Pd in control group was(40.64±5.50ms),which was not significant differences(P>0.05).After the treatment,the numeric value of Pd in treatment group drops down to(37.09±1.38ms)and the numeric value of Pd in the control group was(38.32±1.46ms),which was significant differences,compared with.the number of Pd before the treatment and after the treatment(P<0.05);After treatment,there were ignificant differences in Pd relatively between the treatment group and the control group(P<0.05).2.Pmax:Before the treatment,Pmax of the patients in treatment group was(111.91±8.87ms),while the Pmax in control group was(111.55±7.61ms),which was not ignificant differences(P>0.05).After the treatment,the numeric value of Pmax in treatment group decreases to(104.30±4.57ms)and the numeric value of Pmax in the control group was(107.50±3.78ms),which was ignificant differences,compared with the number of Pmax before the treatment and after the treatment(P<0.05).After treatment,there were ignificant differences in Pmax relatively between the treatment group and the control group(P<0.05).3.LAD:Before the treatment,LAD of the patients in treatment group was(32.20±3.21mm),while the LAD in control group was(31.46±3.45mm),which was not ignificant differences(P>0.05).After the treatment,the numeric value of LAD in treatment group decreases to(32.13±2.97mm)and the numeric value of LAD in the control group was(31.05±3.23mm),which was not ignificant differences,compared with the number of LAD before the treatment and after the treatment(P>0.05).4.Symptom score of TCM and clinical efficacy:Before the treatment,sym-ptom score of TCM of the patients in treatment group was(31.04±3.24),while the symptom score of TCM of the patients in control group was(29.23±2.89),which was not ignificant differences(P>0.05).After the treatment,the numeric value of symptom score of TCM in treatment group decreases to(11±2.94)and the numeric value of sym-ptom score of TCM in the control group was(13.68±2.90),which was ignificant differ-ences,compared with the number of symptom score of TCM before the treatment and after the treatment(P<0.5).On the overall evaluation,the total effective rate of the trea-tment group is 95.6%as 6 casese were obviously effective and 16 cases were effective while only one case is uneffective.The total effective rate of the control group is 72.73%as 1 case was significant effective and 15 cases were effective but 6 cases were uneffective,which were ignificant differences(P<0.05).Conclusions:1.MiGao capsule can further decrease Pd and Pmax in the patients with heart blood stasis syndrome of Paroxysmal atrial fibrillation and reduce the episode frequency of PAF.It also can extend the time to maintain sinus rhythm,which has a better curative effect on the patients with with heart blood stasis syndrome of Paroxysmal atrial fibrillation.2.Migao capsule can significantly improve the clinical symptoms in patients with the heart blood stasis syndrome of PAF and improve the quality of life of patients.Treatment in patients with no significant adverse reaction,which indicates that the programme is clinical safety and worthy to promote.3.The ffect which Migao capsule combined with amiodarone treatment heart blood stasis syndrome of Paroxysmal atrial fibrillation is better than amiodarone alone. |
PDF Full Text Request