Clinical Value Of Expression Of HIF-1 And VEGF In Chronic Obstructive Pulmonary Disease

Objective:To investigate the clinical value about expression of HIF-1 and VEGF in chronic obstructive pulmonary disease Methods:40 patients with acute exacerbation of chronic obstructive pulmonary disease were diagnosed(diagnostic criteria were based on the 2013 version of guideline for the diagnosis and treatment of chronic obstructive pulmonary disease).Exclusion criteria: patients with incomplete medical history data,application of antibiotics within 4 weeks before enrollment,other pulmonary diseases such as bronchial asthma,bronchiectasis,tuberculosis,etc.that can cause similar clinical symptoms;patients with diabetes,coronary heart disease,connective tissue disease and tumor;patients with serious complications occurred during hospitalization and were transferred to the intensive care unit.The subjects were divided into two groups according to arterial oxygen pressure: group I: PaO2>60 mmHg;group II: PaO2<60 mmHg.The patients’ gender,age,smoking index,alcohol abuse history and family history of COPD were recorded.At the day of admission(D0)and the day before discharged(D1),venous blood was drawn from the patients’ peripheral elbow vein,and the levels of HIF-1αand VEGF in peripheral plasma were determined by ELISA.Results:There was no significant difference on patients’ general data such as gender,age,age range(divided by 60 years old),smoking index,alcohol history and family history of COPD between two groups.In group I,on both the first day of hospital admission(D0)and the day before discharge(D1),the arterial pressure of oxygen(PaO2)was significantly higher than that of group II(P<0.05).The arterial blood carbon dioxide pressure(PaCO2)on D0 and D1 was significantly lower than that ingroup II(P<0.05).Compared with group I,the serum expression of HIF-1α in group II on D0 and D1 was significantly up-regulated(P<0.05).Expression of VEGF between two groups was alike as HIF-1α.Spearman rank correlation analysis was applied to explore the arterial oxygen pressure and serum HIF-1α and VEGF levels in the overall sample before any treatments given(n=40).PaO2 and serum HIF-1α and VEGF levels were negative in COPD patients.Correlation(r =-0.8653 and-0.7075,respectively,P<0.05)Conclusion:It was confirmed that the expression of HIF-1 and VEGF in serum of patients with acute exacerbation of chronic obstructive pulmonary disease increased,and decreased after treatment;The lower the arterial oxygen partial pressure in patients with acute exacerbations of COPD,the higher the expression levels of serum HIF-1and VEGF,suggesting that serum HIF-1 and VEGF expression levels may be related to the degree of hypoxia in AECOPD patients.