A Voxel-based Diffusion Kurtosis Imaging Of Study Of Sudden Sensorineural Hearing Loss

Objective:To observe and compare the difference of brain diffusion function between patients with sudden sensorineural hearing loss and normal controls by using voxel-based magnetic resonance diffusion kurtosis imaging(DKI)technique,and to quantitatively calculate and compare the volume of brain regions in patients with sensorineural hearing loss and normal subjects.To explore the adaptation and remodeling of the auditory pathway in the brain area,and to provide reference information for the further study of the mechanism of brain structure and function,such as auditory center and speech center,and so on.In order to provide some theoretical basis for the diagnosis of the disease,assessment of the disease,evaluation of treatment effect and so on.Methods:Sixteen cases of sudden sensorineural hearing loss and 19 cases of the normal control group were collected.Among which 10 cases were effective group and 6 cases were ineffective.All subjects were scanned with rest functional magnetic resonance imaging,and 3D T1WI and DKI images were obtained.Their Ax 3D T1 BRAVO images and Ax DKI 30 Dir images were collected and processed with MATLAB and SPM software package to compare the difference of brain regions between the patients with sudden sensorineural hearing loss and the normal controls.Two groups after pretreatment of the structure image data statistical analysis,using the Rest_V1.8 software Statistical Analysis double sa,mple t-test to obtain the gray matter image data were statistically analyzed.The difference between p<0.01(alphasim correction)and cluster size>20 was statistically significant,and the report forms of differential brain regions were generated,and the coordinates of these brain regions were substituted into Viewer,to check whether the errors were caused by artifact.By setting the relevant parameters of Rest_V1.8 software,the volume of brain area increased and decreased on each parameter map of sudden onset patients was displayed.Results:In the right sudden deafness patients,the left superior temporal gyrus,middle temporal gyrus and infratemporal gyrus,the white matter of the parietal lobe and occipital lobe on the left side of the white matter decreased in FA parameters.In the sudden deafness group,the MK and RK increased in the bilateral frontalis and frontalis,indicating that the projection of the auditory system was bilateral,which coincided with the concept of bilateral projection in neuroanatomy.The parameters of AD,RD,FA,AK,RK,MD and MK in the parietal lobe were changed,and we found that the parameters of MD,AD and RD were decreased,and the parameters on MK,AK and RK were similar,and these parameters were all increased.Moreover,we found that the abnormal brain regions of FA were significantly smaller than those of MD,AD and RD,which indicated that FA was much more accurate than MD,AD and RD in detecting the diffusion of water molecules,while MD,AD and RD showed more abnormal brain areas than MK,AK and RK,indicating that MK could not only reflect the integrity and density characteristics of white matter fiber bundles,but also reflect the changes caused by degeneration,hypertrophy or atrophy.The AD parameters were in the right superior forehead gyrus,the right middle forehead gyrus and the right central posterior gyrus,the RD parameters were in the left cingulate gyrus,the KFA parameters were in the left superior occipital gyrus,the left corner gyrus and the left cingulate gyrus,the MD parameters were in the right ileum and the left middle forehead gyrus,and the MK parameters changed in the left marginal lobe,the right middle forehead gyrus and the right superior marginal gyrus.In the invalid group,the parameters of AD,RD,KFA,MD and MK occurred in the superior,middle and lower temporal gyrus,but there is no change in the occipital lobe and forehead lobe.Conclusion:1.DKI can objectively evaluate the changes of brain function in patients with sudden sensorineural hearing loss,which is helpful to further study the structural changes and remodeling of brain regions after hearing impairment.The abnormal microstructure can be detected to reflect the remodeling and change of the auditory pathway in the brain area.2.DKI can guide the prognosis of patients with sudden sensorineural hearing loss.Patients with parameter changes in temporal lobe,frontal lobe and occipital lobe have better prognosis,only patients with temporal lobe lesion and no remodeling in other brain regions.Failure to re-establish or undertake compensatory hyperplasia,so its prognosis is poor.