Retrospective Clinical Data Analysis Of The Patients With Single Solitary Pulmonary Nodule

Objection:This study aimed to retrospectively analyze the clinical data of patients with single solitary pulmonary nodule,screen out the clinical risk factors of malignant pulmonary nodules,and provide a basis for clinicians to judge benign and malignant pulmonary nodules.Methods:148 cases with solitary pulmonary nodules were selected in our hospital from January of 2016 to June of 2018,all the lesions of these patients were confirmed by surgery,bronchoscope or lung puncture and had definite pathological diagnosis.According to the pathological results,they were divided into benign group(n=40)and malignant group(n=108).The clinical data were collected to judge benign and malignant solitary pulmonary nodules including the patient's gender,age,smoking history,cancer history,family history of cancer,discovery cause of nodules,time between the First detection of pulmonary nodules and medical intervention,maximum diameter of nodules(mm)),location,lobulation,spicule,pleural indentation,vascular convergence sign,tumour markers.Single factor binary regression was performed in the univariate analysis and logistic regression in multivariate analysis of these clincial data,P<0.05 indicates statistical difference.Results:1.A total of 148 patients with pulmonary nodules were collected,1 case underwent fiberoptic bronchoscopy,3 cases underwent lung biopsy and 144 cases underwent surgical resection,including 40 benign and 108 malignant cases,and adenocarcinoma accounted for 97.22%of malignant pulmonary nodules.2.77.03%of pulmonary nodules were found by physical examination,and 22.97%of patients with pulmonary nodules had relevant symptoms when they visited the hospital.Besides,68.52%of patients with malignant pulmonary nodules were found by physical examination,and 31.48%of patients were treated for related symptoms.3.The average time between the first detection of pulmonary nodules and medical intervention by all pulmonary nodules were 172.47days,the average time for benign pulmonary nodules were 123.80 days,and the malignancy were 190.50 days.4.Univariate analysis showed that age,gender,tumour history,maximum diameter of nodules,location,lobulation,spicule,pleural indentation and vascular convergence sign were statistically significant in benign and malignant pulmonary nodules(P<0.05).Multivariate logistic regression analysis showed that gender,age,maximum diameter of nodules,and vascular convergence sign were statistically significant in benign and malignant pulmonary nodules(P<0.05).Conclusion:1.77.03%of pulmonary nodules were found by physical examination,regular physical examination helps early detection of pulmonary nodules.2.The average time between the first detection of pulmonary nodules and medical intervention by all pulmonary nodules were 172.50 days,the average time for benign pulmonary nodules were 123.80 days,and the malignancy were 190.5 days.3.Multivariate regression analysis showed that the patient's gender,age,maximum diameter of nodules,and vascular convergence sign were independent risk factors for malignant pulmonary nodules.