The Analysis Of Risk Factors And Discussion Of Treatment Strategies Of Solitary Pulmonary Nodules

Objective:This study retrospectively analyzed the general Information,imaging, surgical and pathological staging data of patients with solitary pulmonary nodules (SPNs), to hope to discriminate between benign and malignant clinical reference, and provide the basis for further diagnosis and treatment.Methods:From February2012to February2014,160patients with SPNs who were confirmed by biopsy or surgical resection clearly pathological. The following data were collected:1.General information,including gender, age, smoking history, family history of cancer, previous history of cancer, complications, etc.2. Chest CT imaging features, including lung window largest diameter, lesion, spiculation, empty sign, lobulation, pleural indentation and ground glass-like changes, etc., and the maximum diameter measurement analysis mediastinal window/lung window largest diameter (C/T) value.Results:Of160patients, male76cases, female84cases. Benign nodules50cases (31.25%), malignant nodules110cases (68.75%). Malignant nodules, including88 cases of adenocarcinoma (71cases of invasive adenocarcinoma, micro invasive adenocarcinoma in5cases,12cases of adenocarcinoma in situ),9cases of squamous cell carcinoma, small cell carcinoma in3cases,6cases of adenosquamous carcinoma, large cell3cases of cancer, small cell carcinoma mixed adenosquamous carcinoma in1case. Ground glass nodules,6cases of atypical hyperplasia,12cases of adenocarcinoma in situ, micro-invasive adenocarcinoma5cases and29cases of invasive adenocarcinoma. The patient’s age, family history of cancer, previous history of cancer, comorbidities (hypertension or diabetes), CT lung window largest diameter, empty sign, lobulation, pleural indentation and GGO changes in the statistical data of benign and malignant learning differences, and gender, smoking history, and lesion spiculation no statistical difference.98cases with anatomical resection (lobectomy and lung resection), five cases of pulmonary wedge resection. Staging, TisNOMO12cases, T1aNOM035cases, T1aN1M02cases, T1bNOM036cases, T1bNlM02cases, T1bN2M07cases.Conclusion:The general condition of the patient, including age, previous history of cancer, family history of cancer and chest CT in lung window largest diameter, empty sign, lobulation, pleural indentation and ground glass-like changes in the SPN malignant clinical judgment has certain guiding significance. Ground glass malignant nodules, with the increased diameter and the ratio C/T increased, which also increases the degree of infiltration. For the display has a high component density GGO or pGGO malignant SPNs (cT1aNOM0) on CT, particularly limitations pneumonectomy lung resection may have a better prognosis.