Correlation Analysis Between Severity Of Cerebral White Matter Lesion And Serum Cystine C(CysC),Urinary Microalbumin/Creatinine Ratio (ACR) In Patients With Cerebral Infarction

BackgroundWhite matter lesions(WMLs)are common imaging findings of cerebral small vessel disease(CSVD).WMLs are often occult,with no specific clinical manifestations,often asymptomatic in the early stage,and dementia in severe cases.Early gait screening of WMLs has important clinical implications.Both the kidney and the cerebral vascular elastic layer are thin,and have great similarities in anatomy and hemodynamics.They are all target organs of atherosclerosis.Patients with impaired renal function are prone to cerebrovascular diseases such as cerebral infarction,kidney.Changes in function may reflect changes in intracranial blood vessels to some extent.Serum Cystatin C(CysC)and urinary microalbumin/creatinine ratio(ACR)are two newer and more accurate indicators of renal function assessment,which are more and more important and more predictable than creatinine.The risk of heart and cerebrovascular disease in the elderly.At present,there is very little research on the correlation between the degree of renal impairment and WMLs.This study analyzed the correlation between the degree of white matter lesions and renal dysfunction in patients with cerebral infarction,explored the risk factors related to white matter lesions,and looked for relative specificity indicators,which provided a theoretical basis for early screening of WMLs.ObjectiveTo investigate the correlation between WMLs and serum CysC and urinary ACR.MethodPatients with neurological cerebral infarction from October 2017 to October 2018 were enrolled.According to the results of magnetic resonance imaging,they were dividedinto white matter lesions with cerebral infarction group(WMLs group)and large atherosclerotic cerebral infarction group(LAA group).Basic information for each patient,clinical laboratory test results,and head magnetic resonance test results were collected.The correlation between CysC,ACR and WMLs was analyzed;WMLs were further graded to analyze the grade correlation of CysC,ACR and WMLs severity.Result1.After one-way analysis of variance in clinical data of patients with mild,moderate,and severe WMLs,the age,sex,history of hypertension,smoking,alcohol consumption,alanine aminotransferase,aspartate aminotransferase,urea,uric acid,and total cholesterol were found in the three groups.There were no significant differences in indicators such as triglyceride,high density lipoprotein,low density lipoprotein and glycosylated hemoglobin(P>0.05).The CysC and ACR levels of the three groups were compared,and the difference was statistically significant(P<0.01).With the severity of WMLs,the serum CysC level and urinary ACR level were higher,and there was significant difference between the groups(P<0.05).2.The inclusion of CysC and ACR in the logistic regression equation showed that CysC and ACR were independent risk factors for the increased severity of WMLs.Further confirmed by the ROC curve.3.Spearman rank correlation analysis to further clarify the severity of WMLs and CysC and ACR.After further correction of other risk factors,Spearman rank correlation analysis showed that CysC and ACR were positively correlated with the severity of WMLs.(P<0.01).Conclusion1.The higher the level of serum CysC and urine ACR,the higher the possibility of WMLs.2.Serum CysC and urine ACR can be used as independent risk factors for WMLs.3.Serum CysC and urine ACR were positively correlated with the severity ofWMLs.