| Objective: To observe the effect of neoadjuvant chemotherapy on patients with advanced ovarian cancer;various clinical indicators during treatment were collected to explore the factors influencing the patients' prognosis with advanced ovarian cancer.Methods: A retrospective analysis from 2010 on January 1 to December 31,2016 in Anhui provincial hospital focused on amount of 30 patients with advanced ovarian cancer going through neoadjuvant chemotherapy,clinical indicators were compared before and after NACT to see whether all the examination indicators had been improved or not before the cytoreductive surgery.Intraoperative situation had been collected;patients' progression free survival and Overall survival were followed up.Related factors influencing the prognosis of patients were gathered in combination with various indicators.Results: After three standard courses of neoadjuvant chemotherapy,the patients' KPS score,hemoglobin volume,serum albumin volume and laparoscope score were significantly improved compared with those before treatment.Ascites was greatly reduced,Hydrothorax basically disappeared,and primary tumor volume was significantly reduced.In the univariate analysis,which affect the prognosis of patients,serum CA125 level < 35IU/L after neoadjuvant chemotherapy and satisfaction with tumor reduction are favorable factors for the progression free survival.Age not more than 60 years old,FIGO stage: IIIC stage,low serum CA125 and satisfaction with tumor reduction can help improve the overall survival.Conclusion: Neoadjuvant chemotherapy can improve preoperative status of patients,reduce tumor load,narrow surgical range,promove satisfactory tumor reduction,and maintain good postoperative. |
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