The Analysis Of Clinical Features And Risk Factors In Sepsis-Associated Thrombocytopenia

Objective:To explore the clinical features and risk factors of thrombocytopenia in patients with sepsis,and to provide relevant experience for clinical treatment of patients with sepsis.Methods:A retrospective study of 119 patients with sepsis and thrombocytopenia who were treated in our hospital from May 2016 to May 2018 was performed as an experimental group.A retrospective selection of 56 patients with sepsis who were treated in our hospital from May 2016 to May 2018 was selected as a control group.The patient's general information was collected by filling out the questionnaire,including age,laboratory indicators(lowest platelet value,white blood cell count,C-reactive protein,procalcitonin,albuminminimum,lacticacid))thrombocytopenia,thrombocytopenia duration,septic shock,multiple organ failure,APACHE II score?25,no recombinant human thrombopoietin,uncontrolled and uninfused platelets,PCT(procalcitonin,PCT procalcitonin),IL-6 concentration,IL-8 concentration and other data.Univariate analysis of risk factors for sepsis with thrombocytopenia.Statistical analysis of univariate analysis included multivariate analysis using logistic regression models.Results:The comparison of laboratory index data between the two groups showed that there was no statistically significant difference in the minimum value of albumin,lactic acid and white blood cell count between the two groups.The lowest platelet value,procalcitonin and C reaction in the experimental group.The protein data were38.49±21.92,6.53±5.43,and 111.34±66.14.The lowest platelet count,procalcitonin,and C-reactive protein in the control group were 191.23±55.73,3.46±2.62,56.43±45.23,two groups of patients.The difference in platelet minimum,procalcitonin,and C-reactive protein was statistically significant.The death rate was 55.4%,and the control group was 35.7%,suggesting that the death rate of patients with sepsis and thrombocytopenia was lower than that of patients with sepsis without thrombocytopenia(X~2=12.329,P<0.05).Univariate analysis of age,multiple organ failure,APACHE II score?25,and septic shock showed PCT,IL-6 concentration,IL-8 concentration,multiple organ failure,and APACHE II score?25 were risk factors for sepsis with thrombocytopenia.The statistically significant PCT,IL-6 concentration,IL-8concentration,multiple organ failure,APACHE II score?25 in the univariate analysis were included in the logistic regression model for multivariate analysis.The results showed that the age was?65 years old.IL-6 concentration,IL-8 concentration,and multiple organ failure are independent risk factors for thrombocytopenia.Conclusion:The mortality rate of sepsis-related thrombocytopenia is higher in sepsis patients.Age(?65 years old),MODS,APACHE II score(?25),septic shock,IL-6concentration and IL-8 concentration are independent risk factors for thrombocytopenia in sepsis patients.