Clinical Analysis Of Inflammatory Bowel Disease Complicated With Intestinal Dysbiosis

Background Inflammatory bowel diseases(IBD),including Crohn's disease(CD)and ulcerative colitis(UC),is a chronic nonspecific intestinal inflammatory bowel disease,its pathogenesis and cause are not clear at presento?It has the clinical feature of recurrence-relieving-recurrenc?IBD patients are often accompanied by intestinal dysbiosis,which may be related to the pathogenesis and clinical manifestations of IBD.In the treatment of IBD,biological agents,glucocorticoid and immunosuppressant drugs are often used to affect the immune function of patients,which may also be the cause of intestinal dysbiosis?Aim To observe and analyze the clinical characteristics of IBD complicated with intestinal dysbiosis,and to identify the possible influence factors and protective factors affecting intestinal dysbiosis,so as to provide more evidence for clinical treatment of IBD and intestinal dysbiosis.Methods 212 IBD patients in the department of gastroenterology of Nanfang hospital from January 2013 to December 2018 were collected and analyzed retrospectively.According to the dysbacterios degree,they were divided into dysbiosis group I,II,III.The age,gender,course ofdisease,BMI,clinical characteristics and other clinical data of patients in UC and CD groups were compared,and of the two groups were compared.The risk factors of intestinal dysbiosis in UC or CD patients were analyzed by Logistic multivariate regression analysis via.SPSS24.0.The counting data were described by the number of cases and the rate.The difference between the two groups was compared by chi-square test or continuous correction chi-square test or Fisher's exact probability method as the case might be.Measurement data through the normality test to decide whether to adopt the single factor analysis of variance or Kruskal Wallis test,normal distribution data to mean add and subtract the standard deviation to describe,respectively to the UC or CD with intestinal flora imbalance of influence factors for Logistic multi-factor regression analysis and inspection level setting of alpha = 0.05,p<0.05 for the difference was statistically significant.Results 1.Among remission and mild UC patients,the amounts of dysbiosis group?,dysbiosis group ?,dysbiosis group ? are 10(47.6%),11(52.4%),0(0%),respectively;Among moderate UC patients,the amounts of dysbiosis group ?,dysbiosis group ?,dysbiosis group ? are 0(0%),17(81%),4(19%),respectively;Among severe UC patients,the amounts of dysbiosis group ?,dysbiosis group ?,dysbiosis group ? are 3(7.5%),25(62.5%),12(30%),respectively.The degree of dysbiosis is positively correlated with the severity of UC(P<0.001).Univariate analysis was performed on possible influence factor of UC patients complicated with dysbiosis.Disease type and disease site,are possible influence factors of intestinal dysbiosis(P<0.05).Further using logistics multivariate regression analysis,it was concluded that the disease site is the independent influence factor of dysbiosis in UC patients.2?Among remission and mild CD patients,the amounts of dysbiosis group ?,dysbiosis group?,dysbiosis group ? are 26(68.4%),25(33.8%),1(5.6%),respectively;Among moderate CD patients,the amounts of dysbiosis group ?,dysbiosis group ?,dysbiosis group ?are 10(16.2%),41(66.1%),11(17.7%),respectively;Among severe CD patients,the amounts of dysbiosis group ?,dysbiosis group ?,dysbiosis group ? are 32(12.5%),8(50%),6(37.5%),respectively.The degree of dysbiosis is positively correlated with the severity of CD(P<0.001).Univariate analysis was performed on possible influence factorsfen of CD patients complicated with dysbiosis.The use of probiotics within 1 month,previous use of immunosuppressant drugs,high CRP level are possible influence factors of intestinal dysbiosis(P<0.05).Further using logistics multivariate regression analysis,it was concluded that previous use of immunosuppressant drugs and CRP?5mg/L were independent influence factors of dysbiosis in CD patients.Conclusions Chronic relapsing UC and extensive UC may lead to more severe intestinal dysbiosis in UC patients.Previous use of immunosuppressant drugs,and CRP?5mg/L may lead to more severe intestinal dysbiosis in CD patients.