Effect Of Monocyte Count-to-high-density Lipoprotein Cholesterol Ratio On Intracoronary Stent Restenosis

Background: Percutaneous coronary intervention is a sign of modern medical treatment for coronary heart disease,but the postoperative complications of restenosis is still an urgent problem for doctors.Many scholars have pointed out that inflammatory response is one of the important causes of intracoronary stent restenosis,interleukin,chemokines,inflammatory and response markers such as C reactive protein are indicated to the persistence of inflammatory response.Monocyte count-to-highdensity lipoprotein cholesterol ratio is a new index proposed in recent years.Initially,it was used to study cardiovascular complications in patients with renal diseases,and it was found that associated with major adverse cardiovascular events,the severity of coronary artery disease,thrombosis and intracoronary stent restenosis.There are few studies on the relationship between MHR and ISR.The purpose of this study is to research the effect of monocyte count-to-high-density lipoprotein cholesterol ratio on intracoronary stent restenosis.Objective: Retrospectively analyzed the general data,clinical hematological indexes and the characteristics of the intraoperative condition of the patients who successfully received coronary stenting and completed coronary angiography followed up in the Center for Diagnosis and Treatment of Cardiovascular Diseases at the First Hospital of Jilin University.To explore the relationship between MHR and ISR.Methods: Selected 289 patients who first implanted with DES and completed coronary angiography review after more than one year from January 1,2015 to December 31,2017.The diameter stenosis ? 50% within 5 mm before and after the location of stenting was defined as the diagnostic basis of restenosis.General baseline data(including sex,age,hypertension,diabetes,smoking history,family history of coronary artery disease,causes of stent implantation),the first stent implantation and the results of reviewing(including review time interval,vascular lesions,the maximum number of stents in series,maximum length of single stent,the minimum diameter of stents,whether or not restenosis and intimal hyperplasia)were analyzed.Hematological parameters(including urea nitrogen,serum creatinine,total cholesterol,triglyceride,high density lipoprotein,low density lipoprotein,fasting blood glucose,leukocyte count,neutrophil,lymphocyte,monocyte,fibrinogen,pre-interventional monocyte count-to-high-density lipoprotein cholesterol ratio,reviewing monocyte count-to-high-density lipoprotein cholesterol ratio,the increasing change of monocyte count-to-high-density lipoprotein cholesterol ratio)were analyzed to the relationship between various factors and restenosis.Statistical methods were used to draw relevant conclusions and analyze the relationship between various factors and restenosis.Results: 1 A total of 289 cases were included in the study.There were 44 cases in ISR group and 245 cases in non-ISR group.The incidence of ISR was about 15.2%.There were 232 male patients and 57 female patients,aged 60.65 ±9.52 years.And there were no significant different in sex,age,hypertension,smoking history,family history of coronary artery disease and causes of stent implantation between the two groups(P > 0.05).It has significant difference in diabetes between the two groups(P < 0.05).2 There was no significant different in review time interval,vascular lesions,the maximum number of stents in series,maximum length of single stent,the minimum diameter of stents,and whether or not intimal hyperplasia between the two groups(P > 0.05).3 There were no significant different in urea nitrogen,serum creatinine,total cholesterol,triglyceride,high density lipoprotein,low density lipoprotein,leukocyte count,neutrophil,monocyte,fibrinogen,pre-interventional MHR,reviewing MHR,and the increasing change of MHR between the two groups(P > 0.05).There were significant different in fasting blood glucose and lymphocyte between the two groups(P < 0.05).4 Pre-interventional MHR,hypertension,the minimum diameter of stents,vascular lesions and causes of stent implantation were included in multivariate binary Logistic regression analysis.The pre-interventional MHR(P = 0.048,OR= 3.740,95% CI 1.014-13.786)was a risk factor for intracoronary stent restenosis.Conclusion: 1 Pre-interventional monocyte count-to-high-density lipoprotein cholesterol ratio is a risk factor for intracoronary stent restenosis.2 Patients with coronary stent implantation and diabetes are more likely to increasing the probability of intracoronary stent restenosis.3 Patients with ISR have higher fasting blood glucose and lymphocyte count than those with non-ISR.