Comprehensive Analysis And Research On Anthropometric Indexes Of Stroke Risk Prediction

Background and objective:Ischemic stroke has become one of the leading causes of disability and death worldwide.^[1]Stroke has become the leading cause of disability and death among Chinese adults.^[2][3]From 2002 to 2013,the incidence of stroke in China continued to rise^[4],and in the absence of effective preventive measures,it is likely to create an even greater burden of disease in the coming decades.^[5]The etiology of ischemic stroke is unknown,but it is associated with many biological and lifestyle factors,such as hypertension,diabetes,alcohol and smoking,and genetic factors that are involved in the occurrence and development of the disease.^[6][7]Many studies have considered overweight and obesity as risk factors for ischemic stroke.Obesity has been considered as a global epidemic disease^[8][9],and it is a risk factor for the occurrence and development of non-communicable diseases.^[10][11]WHRistheratioofwaist circumference to hip circumference.WHtR is the ratio of waist circumference to height BMI is weight/height squared.This paper compared the value of four anthropometric indicators and their relationship with stroke prevalence in the region.The aim of this study was to find out the index most closely related to stroke and provide reference for the primary prevention of stroke in Jilin province.Methods:This study included 4,052 participants aged 40 years or older in Jilin province,China from January to March 2016.The subject information data including general information,body measurements and laboratory results were collected through face-to-face interviews and physical examinations.Results:For BMI（adjusted OR:1.126,95%CI:0.769–1.648）,waist circumference（adjusted OR:1.324,95%CI:0.883–1.986）,and waist-to-hip ratio（adjusted OR:1.335,95%CI:0.923–1.932）,the patients in the highest quartile did not have a higher risk of stroke than those in the lowest quartile.For waist-to-height ratio,the patients in the highest quartile were more likely have a stroke than those in the lowest quartile（adjusted OR:1.809,95%CI:1.160–2.821）.The area under the curve of waist-to-height ratio,waist-to-hip ratio,waist circumference,and BMI for stroke were 0.627（95%CI:0.595–0.659;sensitivity:65.10%;specificity:56.00%）,0.596（95%CI:0.593–0.629;sensitivity:69.90%,specificity:45.90%）,0.612（95%CI:0.579–0.644;sensitivity:52.70%,specificity:64.70%）,and 0.548（95%CI:0.514–0.583;sensitivity:57.90%,specificity:51.10%）,respectively.Conclusions:WHtR was more strongly associated with stroke risk than other anthropometric measures.