The Prognostic Evaluation Of Mismatch Negativity Combined With Auditory Steady-state Responses In Patients With Severe Cerebrovascular Disease

Object: To analyze the correlation between mismatch negativity and auditory steady-state and prognosis score in patients with severe cerebrovascular disease,and to provide a quantitative evaluation method for prognosis evaluation of patients with severe cerebrovascular disease.Method: 1?Mismatch Negativity From June 2017 to December 2018,patients with severe cerebrovascular disease admitted to NICU of the First Hospital of Jilin University were tested for mismatched negative wave within 72 hours after admission.General information of patients was collected.Glasgow Coma Scale(GCS)was used to test each patient at least once.One month and three months after discharge,patients were followed up by telephone.The prognosis was evaluated by modified Rankin scale(MRs),Glasgow outcome scale(GOS)and Glasgow Coma Scale(GCS).Using the data of patients who completed the first mismatched negative wave detection,compared with the normal control group,to evaluate whether the variables had statistical significance;using the data of patients who completed the second mismatched negative wave,the absolute difference was made before and after,divided by the data of the first detection,the change rate of the data was obtained,and the correlation between the change rate and the prognosis score was analyzed.2?Auditory Steady-state Responses From June 2017 to December 2018,patients with severe cerebrovascular disease admitted to NICU of the First Hospital of Jilin University were examined for auditory homeostasis within 72 hours after admission,and the general information of patients was collected.Glasgow Coma Scale(GCS)was used to test each patient at least once.One month and three months after discharge,patients were followed up by telephone.The prognosis was evaluated by modified Rankin scale(MRs),Glasgow outcome scale(GOS)and Glasgow Coma Scale(GCS).Using the data of patients who completed the first auditory homeostasis test,chi-square test was performed with normal control group,and the data between survival group and death group had no statistical significance.Results: 1?Compared with the death group,there was no significant difference in sex,hypertension,diabetes,coronary heart disease and cerebrovascular disease except whether to use ventilator or or not(P=0.009)and age(P=0.006).2?The amplitudes of PZ and CZ in the mismatched negative wave group were higher than those in the normal control group.3?In auditory homeostasis group,the change rate of PZ latency was strongly negatively correlated with MRs1 m and moderately negatively correlated with MRs3 m.The change rate of CZ latency was strongly negatively correlated with GCS1 m and GCS3 m.4 ? Compared with the control group,the average amplitude/maximum amplitude of patients in the auditory homeostasis group had statistical significance,and the number and maximum amplitude of waves in one second had no statistical significance.Conclusions: 1?The prognosis of the patients was related to the age of the patients and the use of ventilators during hospitalization.2?Amplitude changes of mismatched negative PZ and CZ loci can be used as indicators of brain injury in patients with severe cerebrovascular disease.3?The change rate of PZ and CZ loci latency of mismatched negative wave is related to the prognosis of severe cerebrovascular patients.4?The average amplitude of auditory homeostasis changes in patients with cerebrovascular disease,but the application of auditory homeostasis in the evaluation of cerebrovascular prognosis needs further study.