| ObjectiveThis study aimed to analyze the coronary calcification score(CACS)and coronary computed tomography angiography(CCTA)findings of male and female HIV-infected patients,and further determine whether there are differences in coronary calcification score,plaque characteristics and stenosis between the two groups.MethodsA total number of 158 HIV-infected patients(including 72 females and 86 males)and 102 non-HIV-infected patients(including 49 females and 53 males)with suspected coronary artery disease were enrolled in the study,and non-HIV-infected patients severed as control group.All patients were from Central Plains of China.And all patients underwent the third-generation dual-source computed tomography coronary angiography.Patients were divided into four groups:group A(HIV-infected women),group B(HIV-infected men),group C(non-HIV-infected women),and group D(non-HIV-infected men).CCTA images were analyzed using the modified18-segment model of the American Heart Association(AHA).Statistical significance was established at a p-value less than 0.05.ResultsAccording to the modified 18-segment model of AHA,there were 72 patients,1208 segments for group A,86 patients,1463 segments for group B,49 patients,751segments for group C and 53 patients,829 segments for group D.The patients were between 31-82 years old,17.8-321.1kg/m~2.Male,whether HIV positive or not,were more likely to be current smokers compared with female.There was no significant difference in other clinical data between group A and group B,group C and group D.The prevalence of total plaque and stenosis>50%were hingher in group B than that in group A(P=0.006,0.016).Similarly,in the control groups,the incidence of total plaque and stenosis>50%in group D was significantly higher than that in group C(P=0.001,0.036).Group A had a higher prevalence of non-calcified plaque than group B(P=0.01),and that in group C was significantly higher than that in group D(P=0.038).The prevalence of calcified plaque was 15.1%for group A,19.5%for group B(P=0.003).The incidence of calcified plaque in group D was slightly higher than that in group C,but there was no significant difference.The prevalence of mixed plaque in group A was significantly higher than that in group B(P=0.008),while that in group C was significantly lower than that in group D(P=0.003).The prevalence of CACS more than 0,10 and 100 were 45.8%,43.1%,27.8%in group A and 52.3%,46.5%,43.0%in group B,and there was significant difference between group A and group B with CACS more than 100(P=0.047).The prevalence of calcification score greater than 0,10 and 100 in group C was slightly lower than that in group D,but there was no significant difference.The prevalence of multi-vessel lesion were significantly higher in group B than that in group A(P=0.038),and the prevalence of double-vessel lesion was significantly lower in group C than group D(P=0.034).There was no significant differences in other parameter between group A and group B,group C and group D.After adjusting for traditional cardiovascular risk factors,Logistic regression showed that male was risk factor for total plaque,calcified plaque,obvious stenosis,calcified score greater than 100,three or more vascular lesions,and protective factor for non-calcified plaque and mixed plaque.ConclusionIt is indicated by this study that there are differences in coronary atherosclerosis among different gender HIV-infected patients.HIV-infected male have higher CACS and heavier coronary atherosclerosis burdens.In addition,HIV-infected female have less coronary atherosclerosis burdens,but non-calcified plaque and mixed plaque seem to be more frequently.Men were risk factor for total plaque,calcified plaque,obvious stenosis,calcified score greater than 100,three or more vascular lesions,and protective factor for non-calcified plaque and mixed plaque. |
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