Clinical Study On Treatment Of Chloasma With Liver Stagnation And Qi Stagnation With Facial Acupuncture Combined With Tranexamic Acid Wet Application

Chloasma(Melasma)is a common clinical acquired skin disease of the face,which occurs in women with darker skin color who are frequently exposed to ultraviolet light.The disease is characterized by symmetrical pigmentation spots on the face with irregular scope,which can also be seen in the forehead,eyebrow,zygomaticus,nose and mouth,etc.,with clear boundaries and no self-conscious symptoms.The disease develops slowly and can last for many years.The understanding of chloasma is constantly updated,and there are also a lot of studies,including the possible pathogenesis and various treatment methods,but the pathogenesis has not been fully elucidated.Chloasma currently more treatment methods,but often poor results.This paper innovatively applied facial acupuncture combined with transcripational acid wet application in the treatment of liver stagnation and qi stagnation chloasma.The therapeutic effect was evaluated by the size of skin lesion in the treatment process,color shade,each degree and TCM syndrome score,as well as the safety of the treatment.Literature review comprehensively analyzed the mechanism of facial acupuncture and tranexamic acid in the treatment of chloasma,explored the reasons for the regression of skin lesions and the regression of TCM syndromes,and guided the clinical application with the conclusions obtained from the experiment.Objective: Through the method of facial acupuncture combined with transcriptionacid wet application,the regression of skin lesions and the regression of TCM syndromes of liver stagnation and qi stagnation chloasma were observed,the effectiveness and safety of this method were discussed,and the possible mechanism,advantages,disadvantages and matters needing attention of clinical application were preliminarily explained.Method: This study selected 60 patients admitted to the department of dermatology of wuhan hospital of integrated traditional Chinese and western medicine between July 2018 and March 2019.All cases were definitely diagnosed as chloasma,and all TCM syndromes were identified as liver stagnation and qi stagnation.According to the principle of random control,the patients were divided into two groups: the control group with conventional treatment and the treatment group with facial acupuncture combined with tranexamic acid wet compress.(3)The control group was given vitamin C and vitamin E orally,hydroquinone cream,compound SOD arbutin cream and sunscreen for external use.The experimental group was treated with facial acupuncture and tranexamic acid wet compress on the basis of the treatment plan of the control group.The included cases were treated once every two weeks,and the skin lesion area,color depth of skin lesion,color uniformity of skin lesion,main and secondary syndromes of traditional Chinese medicine were recorded and scored respectively at the initial diagnosis,January,February and march.Adverse reactions during diagnosis and treatment were recorded.Result: the regression rate and total effective rate of skin lesions in the experimental group were higher than those in the control group after 1 month,2 months and 3 months of treatment,with statistical difference(p < 0.05).there was no significant difference between the experimental group and the control group in the regression rate and total effective rate of TCM syndromes(p > 0.05).(3)pairwise comparison was made on the regression of skin lesions in the experimental group after 1 month,2 months and 3 months of treatment.There was no statistically significant difference in the regression of skin lesions after 1 month and 2 months,2 months and 3 months(p > 0.05).There was a statistically significant difference in the regression of skin lesions after 1 month and 3 months(p < 0.05).No adverse reactions occurred in the treatment of the experimental group and control group.Conclusion: the experimental group was better than the control group in the regression of liver stagnation and qi stagnation chloasma skin lesions;there was no statistical difference between the experimental group and the control group in the regression of TCM syndromes of liver stagnation and qi stagnation chloasma;(3)There was a statistical difference in skin lesion regression between the experimental group after 1 month and 3 months of treatment;The treatment in the experimental group was safe and had no side effects.