The Value Of 3D-ASL In Diagnosis Of Ischemic Cerebrovascular Disease

Objective:Compared with the CT perfusion imaging,to evaluate the value of magnetic resonance arterial spin labeling(ASL)perfusion imaging in ischemic cerebrovascular disease.Methods: 36 patients with cerebral infarction were selected,all of them were examined by using GE 1.5T MRI and GE Revolution 256 CT,including T1WI、T2WI、T2 FLAIR、DWI、3D-ASL sequences and one-step CTA-CTP.To draw the area of abnormal perfusion and abnormal high signal as an interest area in DWI imaging and the color perfusion map.Take the mirror area as the control.Assess the vascular stenosis shown by CTA.Compared with the CT perfusion imaging,to analyze the clinical value of ASL in ischemic cerebrovascular disease.Results: 1、All of the 33 cases were positive on DWI,19 cases showed abnormal perfusion at least in one method,and the other 14 cases had no abnormal perfusion(3 infarctions were located in the pons).Among 19 cases with abnormal perfusion,16 cases of two methods showed the same perfusion status(ASL and CTP are all hypoperfusion),3 cases gave different results(2cases ASL hyperperfusion,CTP no abnormal perfusion;1 case ASL no abnormal perfusion,CTP hypoperfusion.),The difference between the two methods showedstatistically significant(p<0.05)in detecting hyperperfusion,but there is no statistically significant difference between the two methods(p>0.05)in detecting hypoperfusion.2、Among 16 cases which showed the same perfusion status,we obtained the size of abnormal perfusion from ASL map and CTP maps,there is no statistically significant difference between ASL-CBF 、 CTP-CBF and CTP-MTT.3、In 16 cases of ASL hypoperfusion,the area of ASL hypoperfusion and DWI high signal were significantly positively related(r=0.729).4、There was no statistically significant difference in 11 cases of DWI positive and perfusion negative between the infarct area and the mirror area.Conclusion:ASL and CTP technique have good consistency in the evaluation of hypoperfusion.ASL not only can provide cerebral perfusion information similar to CTP,but also can effectively reflect abnormal cerebral perfusion and is of great significance in the diagnosis,treatment and prognosis of patients with ischemic cerebrovascular disease.