Preliminary Application Of3D ASL In Study Of Transient Ischemic Attack

PartⅠ The test-retest relability of3D spiral FSE pseudo-continuous ASL oncerebral perfusion in health adultsObjective：To evaluate the test-retest reliability of3D spiral FSE pseudo-continuousASL (3D spiral FSE ASL) in resting state over one week interval. Methods:3D spiralFSE ASL and3D T1-weighted fast spoiled gradient recalled echo (3D T1-FSPGR)sequence were applied to eight healthy subjects twice at the same time each day for oneweek interval. The reliability and reproducibility were evaluated using the voxel-wiseintraclass correlation coefficient (ICC). Results: The brain regions with ICC (0.4-1)were mainly located in the gray matter and white matter of bilateral frontal and temporallobe, the white matter of bilateral parietal and occipital lobe, bilateral cerebellar lobeand brainstem. Conclusion:3D spiral FSE pseudo-continuous ASL was a reliablemethod for assessing cerebral perfusion. Part Ⅱ Preliminary Application of3D ASL in the Perfusion Evaluation ofTransient Ischemic AttackObjective：To evaluate brain perfusion state using3D spiral FSE pseudo-continuousASL(3D ASL) with different post labeling delay time(PLD) time in the patients withTIA. Materials and Methods: Eighteen patients with TIA and22health controls wereperformed with conventional MRI, brain structural imaging and3D ASL (PLD1525ms、2025ms、2025ms). Voxel-based analysis was applied with cerebral blood flow(CBF) images to evaluate the detection efficiency with different PLD time for theabnormal brain perfusion. Results: The decreased brain perfusion was demonstrated inthe patients with TIA compared with health controls. The number of clusters and totalvoxels with increased CBF value were18clusters (1390voxels),24clusters (728voxels) and10clusters (73voxels) for different PLD time (PLD1525ms、2025ms、2525ms), respectively. ROC analysis indicated that3D ASL with PLD1525ms had thebest sensitivity and specificity. Conclusions:3D ASL over the whole brain could beused to detect the abnormal brain perfusion in the patients with TIA, and different PLDtime may had some degrees of impacts on the detection of abnormal brain perfusion. part Ⅲ Comparative study of3D arterial spin labeling perfusion MRI and DynamicSusceptibility Contrast-Enhanced MRI in transient cerebral attackObjective：To evaluate the applicated value of3-dimensional arterial spin-labeled (3DASL) compared with dynamic susceptibility contrast-enhanced (DSC) imaging intransient cerebral attack（TIA）.Materials and Methods: Ten patients with TIA wasapplied with conventional MRI, brain structural imaging and3D ASL (PLD1525ms、2025ms、2525ms) and DSC MR imaging. Abnormal brain perfusion was obsered usingvisual evaluation, and CBF value of the decreased CBF region and contralateral mirrorregions were measured and rCBF was computed. Results: Eight cased of10cases hada consistent presention (abnormal perfusion6cases, normal perfusion2cases), and2cases had inconsistent appearance. The quantitative analysis demonstrated that therewas no significant difference between the two methods (P>0.05). Conclusion:3D ASLand DSC-PWI two kinds of methods to determine perfusion perfusion in patients withTIA consistency. Conclusion:3D ASL perfusion imaging is consistent with DSCperfusion imaging in TIA patients.3D ASL perfusion imaging could be quantitativelyused to evaluate the brain perfusion state in TIA.