Relationship Between Preoperative Plasma FIB,DD Levels And Coagulation Score And Prognosis Of Colorectal Cancer

Objective: to investigate the relationship between preoperative plasma FIB,DD levels,coagulation score and prognosis of postoperative colorectal cancer.Methods: 631 cases of colorectal cancer hospitalized in the first affiliated Hospital of Guangxi Medical University from 2012.09 to 2014.09 were analyzed retrospectively.To study the relationship between preoperative plasma FIB,DD levels,coagulation score and clinicopathological data and postoperative prognosis of colorectal cancer.The analysis software is SPSS22.0.Results:1 ? Preoperative intestinal obstruction,T stage,TNM stage,distant metastasis and tumor location were significantly correlated with preoperative D-dimer positive in colorectal cancer(P < 0.05),but sex,age,HB classification,PLT classification,N stage and nerve Invasion,vascular invasion,gross pathological type and tissue differentiation were not significantly correlated with the positive expression of D-dimer before operation(P > 0.05).2?Age,intestinal obstruction,HB classification,PLT classification,T stage,distant metastasis,tumor location and tissue differentiation were significantly correlated with preoperative plasma FIB positive(P < 0.05),sex,N stage,TNM stage,nerve invasion and vascular invasion,gross pathological type were not significantly correlated with preoperative plasma FIB positive(P > 0.05).3 ? Coagulation score was significantly correlated with age,intestinal obstruction,HB,PLT,T stage,distant metastasis,tumor location and tissue differentiation(P < 0.05).But not significantly correlated with sex,N stage,nerve invasion,vascular invasion and pathological type(P > 0.05).4 ? According to the coagulation score,the variables with significant difference in the whole were compared.the results showed that there were significant differences in intestinal obstruction,PLT classification and distant metastasis distribution between 0 / 1 group and 0 / 2 group,but there was no significant difference in 1 / 2 score.There was significant difference in T stage between 0 / 2 group and 1 / 2 group,but there was no significant difference in 0 /1 score.There were significant differences in age distribution and tissue differentiation between 0 / 1 group,but no significant difference in 0 / 2 and 1 /2 groups.There was significant difference in Hb and tumor location between 0and 2,but there was no significant difference in 0 / 1 and 1 / 2.5?Univariate analysis showed that intestinal obstruction,coagulation score,FIB,PA,T stage,TNM stage,distant metastasis,vascular invasion and tissue differentiation had significant effects on prognosis(P < 0.05).Age,sex,HB,PLT,DD classification,tumor location,nerve invasion,gross pathological type and postoperative adjuvant therapy had no significant effect on prognosis(P > 0.05).6?In multivariate analysis,N stage(Exp(B)= 1.979,95% CI ? 1.586 ?2.470,P < 0.001),distant metastasis(Exp(B)= 4.611,95% CI ? 3.062 ? 6.943,P < 0.001),preoperative FIB classification(Exp(B)= 1.518,95% CI ? 1.031 ?2.236,P ? 0.034)were independent prognostic factors for patients with colorectal cancer.Intestinal obstruction,coagulation score,PA,T stage,,TNM stage,vascular invasion and tissue differentiation were not independent prognostic factors in patients with colorectal cancer.Conclusion:1.preoperative fibrinogen,D-dimer and coagulation score were significantly correlated with preoperative intestinal obstruction,T stage,distant metastasis and tumor location.In addition,fibrinogen level and coagulation score were also correlated with advanced age,preoperative anemia,hyperthrombocytopenia,hypoalbuminemia and poor tissue differentiation,and D-dimer level was also correlated with TNM stage.High coagulation score was significantly correlated with preoperative anemia,tumor distribution in the right colon,and deeper depth of invasion.2.lymph node stage,distant metastasis and preoperative plasma fibrinogen level are independent risk factors for prognosis of patients with colorectal cancer,while preoperative D-dimer level and preoperative coagulation score can not independently predict the prognosis of patients with colorectal cancer.