Clinical Study Of QTc Interval And Nonalcoholic Fatty Liver Disease In Type 2 Diabetes Mellitus Patients

Background and ObjectivesNonalcoholic fatty liver disease(NAFLD)is the most common disease of abnormal liver function in many countries.Recently,with the change of eating habits and lifestyles,NAFLD has became a major public health problem.NAFLD is not only associated with liver complications such as cirrhosis and hepatocellular carcinoma,but also with many extrahepatic complications including type 2 diabetes mellitus(T2DM)and cardiovascular disease(CVD).Corrected QT(QTc)interval is defined that the total time course of ventricular myocardial depolarization and repolarization.QTc interval prolongation on the standard Electrocardiogram(ECG)is considered to increase the risk of malignant ventricular arrhythmia.Prolongation of QT interval was also a significant predictor of cardiac death.Studies reported that the proportion of T2 DM patients with QTc prolongation in Italy and China was 26% and 30%,respectively.The current study has confirmed that NAFLD has a correlation with the prolongation of QTc interval.However,there are few clinical studies working on QTc interval and NAFLD in T2 DM patients.The purpose of this studywas to investigate whether NAFLD is an independent risk factor for QTc prolongation in patients with T2 DM,and to further establish the risk of arrhythmia in T2 DM patients with NAFLD.MethodsThis study collected the complete relevant medical history data and examination results of 753 samples of T2 DM patients who hospitalized in the Gastroenterology Department and Endocrine Department of the Fifth Affiliated Hospital of Zhengzhou University from March 2017 to June 2018.The QTc interval >440ms was the QTc+ group,the QTc interval ?440ms was the QTc-group.All the data was analyzed through Statistical Product and Service Solutions(SPSS)software version 22.Factors that may affect QTc interval,such as gender,heart rate,red blood cells,hemoglobin,were analyzed by Logistic regression analysis to analyze the protection and risk factors of prolonged QTc interval in patients with T2 DM.The R software(version 3.5.1)is used to read SPSS type data files and further analysis is then carried out.The R language interpreter used is RStudio(version 1.1.442).ResultsMale(OR=0.201,95%CI 0.112-0.361,P<0.001),elevated creatinine(OR=0.937,95%CI 0.855-1.027,P<0.001),elevated red blood cell count(OR=0.299,95%CI 0.116-0.768,P=0.012)were protective factors for QTc interval prolongation in patients with type 2 diabetes.Elevated age(OR=1.040,95%CI 1.017-1.062,P<0.001),elevated heart rate(OR=1.045,95%CI 1.028-1.062,P<0.001),elevated uric acid level(OR=1.003,95%CI 1.001-1.005,P=0.005),elevated hemoglobin(OR=1.032,95% CI 1.000-1065,P<0.001),obesity(OR=5.623,95% CI 2.794-11.317,P<0.001)and NAFLD(OR=1.935,95%CI 1.204-3.110,P=0.006)were risk factors for QTc interval prolongation in patients with type 2 diabetes.It is a remarkable fact that NAFLD was an independent risk factor for QTc intervals prolongation in patients with T2 DM.There was no correlation between QTc interval prolongation and BMI,hypertension,smoking and other factors(P>0.05).ConclusionQTc interval was longer in T2 DM patients with NAFLD compared with T2 DM patients alone.This study concluded that NAFLD was an independent risk factor for QTc intervals prolongation in patients with T2 DM.