| ObjectiveTo study the association of serum thyroglobulin antibody(TgAb)with the risk of every kinds of thyroid cancer(TC)in patients with thyroid nodule(TN).MethodsThe benign or malignant of thyroid nodule was confirmed by the postoperative histopathology examination of thyroidectomy tissue.The level of serum thyroglobulin antibody was tested by Electrochemiluminescence immunoassay in 1257 patients that have operation in department of thyroid surgeryⅡ,First Affiliated Hospital of Zhengzhou University from 2015.09.01 to 2016.12.31.A retrospective cohort analysis was performed,the correlations of the level of serum TgAb with the benign rate or malignant rate of thyroid nodule was determined by Chi-square test and other kinds of test.ResultsAmong the 1257 patients,there were 196 patients whose TgAb level was high.Among these 196 patients,there were 94 patients with benign TN,benign rate was 47.96% and there were 102 patients with malignant TN,malignant rate was 52.04%.There were also 1061 patients whose TgAb level was normal,among these 1061 patients,there were 654 patients with benign TN,benign rate was 61.64% and there were 407 patients with malignant TN,malignant rate was 38.36%.For(papillary thyroid carcinoma,PTC),χ2≈23.1019,OR≈1.7218,the 95%CI of OR is(1.3829,2.3754).For(follicular thyroid carcinoma,FTC),χ2≈0.2875,P﹥0.01.For(medullary thyroid carcinoma,MTC),P≈0.0489﹥0.01.ConclusionAmong the paitents with TN,PTC rate of the patients whose serun TgAb level is high is higher than the patients whose serum TgAb level is normal.But among the paitents with TN,we do not think that FTC and MTC rate of the patients whose serun TgAb level is high is higher than the patients whose serum TgAb level is normal. |
