The Clinical Research Of Morinda Oficinalis Oligosaccharide Capsule In Treating Mild And Moderate Depression Of Kidney-Yang Deficiency

Objective:To study the clinical efficacy of Morinda Officinalis Oligose Capsule in the treatment of kidney yang deficiency pattern light and moderate depression.and the safety of Morinda Officinalis Oligose Capsule was evaluated objectively.Methods: The 194 subjects enrolled in this study were randomly divided into observation group and positive control group,97 cases in each group.Observation group medication: Morinda Officinalis Oligose Capsule(Beijing Tong Ren Tang),initial amount: Morinda Officinalis Oligose Capsule 150 mg,one each morning and evening;Incremental: Morinda Officinalis Oligose Capsule 300 mg,one each morning and evening.Positive control group: Paroxetine hydrochloride tablets 20 mg,one time a day,taking in the morning.Throughout the study period are not allowed to add any other Antipsychotice,antidepressant,mood stabilizers and cerebral stimulant,disable affect the outcome of the traditional Chinese medicine or health products;Disable system psychotherapy,electric convulsive treatment,all kinds of physical therapy.For the more serious insomniacs,you can use a short effect sedative such as Dexzopiclone Tablets,which can only be taken before bed and detailed in the personal data.The treatment time was 8 weeks.After The treatment,The statistical group and positive control group subjects before and after The treatment of Hamilton 'scale(HAMD),The scale of kidney Yang deficiency syndrome in Chinese Medicine and The Hamilton anxiety scale(HAMA)score,and to compare The curative effect of two groups of drugs.Treatment in patients with detailed records produced by the reaction,detection compared two groups of patients before and after treatment of Numeration et Formule Sanguin,routine urinalysis,liver function,takes the function,the electrocardiograph to objectively assess the safety of the drug.Results: 1.Curative effect evaluation: 8 weeks after treatment,two groups of per capita can reduce HAMD score,The scale of kidney Yang deficiency syndrome in Chinese Medicine and HAMA scores,treatment before The difference had statistical significance(P < 0.05),Morinda Officinalis Oligose Capsule and Paroxetine Hydrochloride Tablets and effective treatment of kidney Yang deficiency pattern mild-to-moderate ';In the HAMD score,the total effective rate of the observation group was 82.11%,and the total effective rate of positive control group was 83.33%.In the scale of kidney Yang deficiency syndrome in Chinese Medicine,the total effective rate of the observer group was 88.42%,and the total effective rate of positive control group was 89.58%.In the HAMA score,the total effective rate of the observer group was 78.95%,and the total effective rate of positive control group was 81.2%.Among the three.Two group total effective rate difference has no statistical significance(P > 0.05),and prove that Morinda Officinalis Oligose Capsule in the treatment of kidney Yang deficiency pattern mild-to-moderate ',curative effect is not bad in the positive control drug Paroxetine Hydrochloride Tablets.2.Safety decision: during the trial,three subjects showed aphthous stomatitis,severe insomnia,nausea and stomach discomfort,and continued to take medication after treatment.There was no statistically significant difference between the observer group and the positive control group safety evaluation index before and after treatment(P >0.05).Conclusion: Morinda Officinalis Oligose Capsule and Paroxetine Hydrochloride Tablets are safe and effective.