Objective To Evaluate The Diagnostic Value Of MLR And PLR Combined With Serum CA125 In Epithelial Ovarian Cancer

Purpose:Objective to evaluate the value of peripheral blood monocyte/lymphocyte ratio(MLR),platelet/lymphocyte ratio(PLR)combined with serum CA125 in the diagnosis of epithelial ovarian cancer,so as to provide evidence for early diagnosis of ovarian cancer and increase the accuracy of ovarian cancer diagnosis.Methods:From January 1,2014 to January 1,2016,110 patients with epithelial ovarian cancer were admitted to the gynecology and obstetrics department of the First Affiliated Hospital of Nanchang University.They were selected as malignant tumors group.At the same time,110 patients with benign ovarian tumors were selected as benign tumors group.110 healthy women were taken as control group.Clinical data of the three groups of patients were collected through the medical record management system,including pretreatment blood routine and serum CA125,and MLR and PLR of each patient were calculated.Nonparametric Test(mann-whitney U Test)was used to analyze the differences of Test indexes in each group.Meanwhile,ROC curve and Logistic regression were used to analyze the diagnostic value of MLR,PLR and CA125 for epithelial ovarian cancer.Through follow-up,patients in the malignant tumor group were divided into the recurrence group and the non-recurrence group,and MLR and PLR of the two groups were compared with or without statistical differences.Results:1.The number of mononuclear cells,CA125 and MLR values in the malignant tumor group were all higher than those in the benign tumor group and the healthy control group,with statistically significant differences(P<0.01),there was no significant difference between the benign tumor group and the healthy control group(P>0.05).The number of platelets in malignant tumor group was higher than that in healthy control group,and the difference was statistically significant(P<0.01),and there was no significant difference between the malignant tumor group and the benigntumor group(P > 0.05).The number of lymphocytes in malignant tumor group was smaller than that in benign tumor group and healthy control group,and the difference was statistically significant(P<0.01),there was no significant difference between the benign tumor group and the healthy control group(P>0.05).PLR values of the three groups were different,PLR value of malignant tumor group was greater than that of benign tumor group(P<0.01),and PLR value of benign tumor group was greater than that of healthy control group(P<0.01).2.By ROC curve analysis,the benign ovarian tumor group was used as the reference group,the AUC of MLR,PLR and CA125 for the diagnosis of epithelial ovarian cancer were 0.784,0.601 and 0.919,respectively(P<0.01).The AUC of MLR combined with PLR and combined with three indexes were 0.785 and 0.946,respectively(P<0.01).Combined diagnosis is better than single diagnosis.3.The cut-off values of MLR,PLR,CA125,MLR combined with PLRand the combined diagnosis of epithelial ovarian cancer were 0.29,162.34,56.00,0.68 and0.27,respectively,according to the ROC curve.The sensitivity was 74.5%,90.9%,93.6%,53.6% and 98.2%,respectively.The specificity was 70.9%,30.9%,77.3%,91.8% and 80.0%,respectively.The positive predictive values were 71.9%,56.8%,80.5%,83.1%,64.7%,and the negative predictive values were 73.6%,77.3%,92.4%,65.8%,96.2%,respectively.4.MLR and PLR in ?,? stage epithelial ovarian cancer patients is lower than? period,? period,the difference was statistically significant(P < 0.05).The MLR and PLR of the patients with ideal surgery were lower than those without ideal surgery,and the difference was statistically significant(P < 0.01).After follow-up for6 months or more,patients with cancer recurrence had higher MLR and PLR than those without recurrence,and the difference was statistically significant(P <0.01).There was no significant difference in MLR and PLR between patients with serous ovarian cancer and those with non-serous cancer(P>0.05).Patients were divided into two groups according to age: ?50 years old group and <50 years old group.There was no significant difference in MLR and PLR between the two groups,and the difference was not statistically significant(P>0.05).Conclusions:1.MLR and PLR were different in patients with epithelial ovarian cancer,benign ovarian tumor and healthy population.Both MLR and PLR in patients with epithelial ovarian cancer were larger than that in patients with benign ovarian tumor and healthy population.2.MLR and PLR have certain value in the diagnosis of epithelial ovarian cancer.Combined diagnosis of MLR,PLR and CA125 can improve the sensitivity and specificity of the three indicators in the independent diagnosis of epithelial ovarian cancer,and can improve the accuracy of the diagnosis of epithelial ovarian cancer.3.MLR and PLR were related to the clinical staging,surgical ideal degree and postoperative recurrence of epithelial ovarian cancer.