Clinical Investigation On Carotid Elasticity Measured By Ultrafast Imaging Technology In Patients Treated With Maintenance Hemodialysis

Objective:1.The elasticity of common carotid artery in healthy adults was quantitatively evaluated by ultrafast imaging(UFI)technique and the influencing factors of the elasticity of common carotid artery in healthy adults were discussed.2.UFI technique was used to evaluate the elasticity of the common carotid artery in patients treated with maintenance hemodialysis,and to explore the influencing factors of the elasticity of the common carotid artery,so as to provide an objective theoretical basis for early prevention of cardiovascular risk events in patients with treated maintenance hemodialysis.Methods:Part ? Evaluating the elasticity of carotid arteries in healthy adults by ultrafast imaging techniqueA total of 73 healthy adults with normal physical examinations were collected,including 34 males and 39 females.The subjects were respectively divided into 4groups according to gender and age.The ages were divided into 4 groups: 20-29 years old group(n=22),30-39 years old group(n=20),40-49 years old group(n=17),50-72 years old group(n=14).Intima-media thickness(IMT)was measured by conventional ultrasound.UFI technique was used to measure the common carotid arterial UFPWV,including the pulse wave velocity-beginning of the systole(PWV-BS)and ending of the systole(PWV-ES).UFPWV,IMT between different gender and age were compared.The correlations among age,IMT and UFPWV were analyzed.Part ? Clinical investigation on carotid elasticity measured by ultrafast imaging technology in patients treated with maintenanceh emodialysisThe 60 patients who were collected from our hospital for long-term hemodialysis were the case group.73 healthy adults with age and gender matching were the normal controls.Clinical and biochemical data were collected.IMT was measured by conventional ultrasound.If the plaque exists,the maximum transverse section thickness of plaque will be recorded as IMT.The common carotid arterial UFPWV were evaluated by UFI technique,including the pulse wave velocity-beginning of the systole(PWV-BS)and ending of the systole(PWV-ES).Clinical data,biochemical data,the common carotid arterial UFPWV and IMT between MHD patients and the normal controls were compared.The correlations among age,IMT,pulse pressure,dialysis age.Results:Part ? Evaluating the elasticity of carotid arteries in normal healthy adults by ultrafast imaging technique1.There was no significant difference in UFPWV and IMT between the left and right common carotid arteries(P>0.05).2.There was no significant difference in UFPWV between different gender groups(P>0.05).3.There was significant difference in UFPWV(PWV-BS: F=26.7;PWV-ES:F=48.3,P<0.001)among different age groups;UFPWV was positively correlated with age(PWV-BS: r=0.77;PWV-ES: r=0.85,P <0.05).4.There was difference in IMT among different age groups(F=4.0,P<0.05).UFPWV was positively correlated with IMT(PWV-BS: r=0.46;PWV-ES: r=0.40,P<0.05).Part ? Clinical investigation on carotid elasticity measured by ultrafast imaging technology in patients treated with maintenance hemodialysis1.There was no significant difference in age,BMI,fasting blood glucose,total cholesterol,high-density lipoprotein,blood calcium and blood phosphorus between the two groups(P>0.05).The difference in pulse pressure,hemoglobin,triglyceride,low-density lipoprotein and serum creatinine were statistically significant(P < 0.05).2.There was no significant difference in UFPWV and IMT between the left and right sides of the MHD group(P>0.05).3.The UFPWV and IMT of the MHD group were significantly higher than the normal controls,and the difference was statistically significant(P<0.005).4.The UFPWV of MHD group with IMT<1.0mm and IMT were higher than the control groups,the difference was statistically significant(P<0.005).There was no significant difference in UFPWV between 40 patients with IMT<1.0mm and 20 patients with IMT?1.0mm.(P>0.05).5.UFPWV in patients treated with MHD was positively correlated with age(PWV-BS: r=0.431;PWV-ES: r=0.361),dialysis age(PWV-BS: r=0.422;PWV-ES:r=0.516),pulse pressure(PWV-BS : r = 0.465;PWV-ES: r = 0.523),P< 0.05;but not correlated with BMI,IMT,hemoglobin,blood phosphorus,blood calcium,fasting blood glucose,total cholesterol,triglycerides,low density lipoprotein,high density lipoprotein(P>0.05).Further analysis found that 40 patients with IMT<1.0mm were positively correlated with UFPWV(PWV-BS: r=0.412;PWV-ES:r=0.743,P<0.005);20 patients with IMT?1.0mm had no significant correlation with UFPWV(P>0.5).6.Multiple linear regression results were showed that age and dialysis age were independent factors influencing UFPWV in patients treated with MHD.The regression equations were: Y(PWV-BS)=5.004+0.022×age+0.006×dialysis age,Y(PWV-ES)=5.583+ 0.035×age+0.015×dialysis age.Conclusion:1.There was no significant difference in UFPWV and IMT between the left and right common carotid arteries in normal healthy adults and patients treated with MHD.2.UFI technology could quickly and accurately evaluate the elasticity of common carotid arteries in healthy adults.The measured value was related to age and IMT,but not gender.3.UFPWV of patients treated with MHD was significantly greater than the contrast,suggesting that the arterial elasticity of the patients was significantly reduced.4.Age and dialysis age were factors influencing carotid elasticity of patients treated with MHD.5.The elastic function of the aorta had significantly reduced before the wall structure changes in patients treated with MHD,suggesting that UFI technology can quantitatively evaluate the carotid elasticity of patients treated with MHD at an early stage,which may provide an objective basis for early preventing cardiovascular risk events in patients with maintenance hemodialysis.