Correlation Between Metabolic Syndrome And Serum Bilirubin In Dehui Residents

Objective: To explore the correlation between metabolic syndrome(MS)and serum bilirubin,and provide a scientific basis for the prevention and treatment of metabolic syndrome.Methods: Epidemiological surveys were conducted for urban and rural residents over 20 years old in Dehui City,Jilin Province.Random survey sampling method was used for questionnaire survey,anthropological index measurement and relevant hematological examination.A total of 1392 subjects were enrolled in the study.A total of 1,197 patients who met the criteria were included in the study after excluding those with a history of chronic liver disease,those with obvious abnormal liver function due to various reasons,and those with related diseases that might affect the examination results,and those with incomplete data.Metabolic syndrome was diagnosed according to the diagnostic criteria for metabolic syndrome in the Guidelines for the Prevention and Treatment of Type 2 Diabetes in China(2013 edition).SPSS 19.0 statistical software was used for data analysis.Data of continuous variables were expressed as mean standard deviation,and classified variables were expressed as percentage,the t-test was used to evaluate the differences between the two groups,and the chi-square test was used for the comparison of the two samplerates.Correlation analysis was performed using multiple linear regression.P<0.05 represents statistically significant.Results: 1.The prevalence of metabolic syndrome in the study population was 25.6%,of which the male prevalence rate was 23.7% and the female prevalence rate was 27.1%.T The prevalence of female metabolic syndrome was higher than that of males,but there was no statistical difference between the sexes(P>0.05).The prevalence of MS in the study population was statistically different in different ages,occupations,and educational levels(P<0.05).2.According to the diagnostic criteria of metabolic syndrome in the Guidelines for the Prevention and Treatment of Type 2 Diabetes in China(2013 edition),the study population was divided into MS group and NMS group.Age,abdominal circumference,systolic blood pressure,diastolic blood pressure,cholesterol,triglyceride and fasting blood glucose of the MS group were all higher than those of the NMS group,and the differences were statistically significant at P < 0.05.While,serum direct bilirubin and high-density lipoprotein were lower than those of the NMS group,and the differences were statistically significant(P < 0.05).3.Multiple linear regression analysis of serum direct bilirubin and MS components showed that there was a linear relationship between high-density lipoprotein and fasting blood glucose and serum direct bilirubin.Serum direct bilirubin level increased with theincrease of high-density lipoprotein and decreased with the increase of fasting blood glucose,and both of them were statistically significant at P < 0.05.4.According to the serum level of direct bilirubin,the subjects were divided into four groups by quartile method: DBIL ? 3.0ummol/L for Q1 group,3.0ummol/L < DBIL ? 4.0ummol/L for Q2 group,4.0ummol/L < DBIL ? 6.0ummol/L for Q3 group,DBIL > 6.0ummol/L for the Q4 group,and the prevalence of metabolic syndrome was 26.2%,32.1%,26.7%,14.8%,respectively.There was a statistically significant difference between the different direct bilirubin groups at P < 0.05,among them,the direct bilirubin level had the lowest MS prevalence in the Q4 group.5.According to the difference of the number of MS components,the respondents were divided into 0 group,1 group,2 group and ? 3 group.Among them,the serum direct bilirubin level of ? 3 was group was significantly lower than that of 0 group,1 group and 2 group,and the difference was statistically significant(P < 0.05).The results showed that the direct bilirubin level decreased with the increase of the number of MS components.Conclusion: 1.The prevalence of syndromes in the subjects differed in age,occupation,education level.Among them,the prevalence of MS was high in the elderly,people with mental work,low education,smoking and lack of exercise.2.The level of direct bilirubin in the metabolic syndrome group was lower than that in the non-metabolic syndrome group.3.The prevalence of MS in the high-concentration direct bilirubin level in the physiological range was significantly lower than that in the other two groups.4.As the number of MS components increased,the level of direct bilirubin initially showed a downward trend.5.There was a linear relationship between HDL and fasting blood glucose and direct bilirubin level,in which direct bilirubin level was positively correlated with HDL and negatively correlated with fasting blood glucose.6.High concentration of direct bilirubin in the physiological range is a protective factor for metabolic syndrome.