Clinical And Pathological Analysis Of Patients With IgA Nephropathy And Dyslipidemia

Objective: To investigate the relationship between dyslipidemia and clinical manifestation or pathological classification.Methods: 91 patients diagnosed with IgA nephropathy by renal biopsy,were collected from China-Japan Union Hospital from June 2014 to December 2018.The patients were divided into normal blood lipid group and dyslipidemia group according to blood lipid levels.The general clinical data,baseline laboratory parameters and pathological data of the two groups were recorded in detail.The differences of general clinical data,relevant laboratory indicators and pathological grades between two groups were analyzed subsquently.Correlation analysis of these statistically significant parameters with triglycerides,cholesterol,HDL-C,and LDL-C were performed.The guiding significance of different blood lipid indicators for judging IgAN disease were explored.The data was analyzed with SPSS 22.0 statistical software and P<0.05 was considered statistically significant.Results: 1.Among 91 patients with IgAN,there were 38 patients had normal blood lipids and 53 patients had dyslipidemia.The proportion of patients with dyslipidemia was 58.24%.The dyslipidemia group included 10 cases of hypercholesterolemia(18.87%),13 cases of hypertriglyceridemia(24.53%),7 cases of mixed hyperlipidemia(13.21%)and 23 cases low-high-density lipoprotein cholesterolemia(43.39%).Low-high-density lipoprotein cholesterolemia accounts for the highest proportion of dyslipidemia and followed by hypertriglyceridemia.2.The gender ratio and body mass index were significantly different between patients with dyslipidemia and normal blood lipids(P<0.05).And the male patients were more likely to have dyslipidemia.The body mass index was higher in patients with dyslipidemia than that of normal blood lipids group.There was no significant difference between the two groups in age(P>0.05).3.The serum creatinine,urea nitrogen,24-hour urine protein quantitation,blood uric acid and IgA/C3 ratio were higher in the dyslipidemia group than in the normal blood lipid group and the estimated glomerular filtration rate was lower than that in the normal blood lipid group.The difference was statistically significant(P<0.05).There was no significant difference in serum albumin and hemoglobin between the two groups(P>0.05).4.There was a statistically significant difference in the composition ratio of different stages of CKD and different pathological grades between the two groups(P<0.05).5.There was a statistically significant difference in the correlation analysis between triglyceride and body mass index,serum creatinine,blood urea nitrogen,blood uric acid,24-hour urine protein quantitation,IgA/C3 and estimated glomerular filtration rate(P<0.05).Conclusion: 1.The prevalence of hyperlipidemia in patients with IgA nephropathy is high,and male patients are more prone to dyslipidemia.The main type of dyslipidemia is low HDL-C,followed by hypertriglyceridemia.2.Dyslipidemia is closely related to 24-hour urine protein quantitation,estimated glomerular filtration rate,serum creatinine and renal pathological grade.And the prevalence of dyslipidemia increases as renal function progresses.3.Triglycerides were positively correlated with body mass index,blood uric acid,24-hour urine protein quantitation,IgA/C3,blood urea nitrogen and serum creatinine,and negatively correlated with estimated glomerular filtration rate.4.Dyslipidemia may be one of the risk factors for predicting IgA nephropathy,and tariglyceride can be used to predict the progression and prognosis of IgA nephropathy.