Dyslipidemia And Its Correlation With The State Of Micro Inflammation In Patients With Middle And Late Chronic Kidney Disease

1 purposesTo compare the characteristics of dyslipidemia in different stages of CKD(Chronic kidney disease),the relationship between dyslipidemia and the progression of chronic kidney,and to explore the correlation between dyslipidemia and micro inflammation in chronic kidney disease.To guide the prevention and treatment of dyslipidemia in middle and late chronic renal disease,and to provide ideas for slowing down the progression of renal function in patients with chronic kidney disease.2 methodThis study selected 91 middle and late(CKD,Chronic kidney disease)patients in the First Affiliated Hospital of Bengbu Medical College,of which 38 were female and 53 were male,with an average age of 59.54 + 16.70 years.According to the staging criteria of renal function,they were divided into three groups: CKD3 stage 19 cases,CKD4 stage 27 cases,CKD5 stage 45 cases.According to the blood lipid level,the blood lipid level was divided into the hyperlipidemia group and the normal blood lipid group;According to the difference of the primary disease,the primary disease was divided into the chronic glomerulonephritis group,the hypertension group and the diabetic group;At the same time,according to the different complications,they were divided into hypertension group,coronary heart disease group and diabetes group.Meanwhile,25 healthy persons in the same period in our hospital were selected as control group.All the subjects were selected to take the early morning venous blood,and measure the serum urea nitrogen(BUN),serum creatinine(Scr),serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL C),low density lipoprotein cholesterol(LDL C),lipoprotein a(Lpa),C-reactive protein(CRP).3 Results1.There was no significant difference in the general parameters of sex,age and weight between the CKD3-5 phase and the normal control group(P>0.05).2.The levels of serum lipids and micro inflammatory indexes in patients with advanced CKD were significantly lower than those in the control group(P<0.05),and the levels of HDL-C in each stage of CKD3-5 were significantly lower than those in the control group(P<0.05).The levels of serum TC,TG,Lpa and CRP in CKD3-5 patients were significantly higher than those in the control group(P<0.05),and Lpa and CRP decreased with eGFR.There was a significant difference between the CRP level and the CKD5 phase(P<0.05).During the period of CKD The increase of TG and HDL was the main stage in CKD3 stage,and the level of HDL,Lpa and TG increased mainly in CKD4 and 5 stage.3.The cases of 91 patients with advanced CKD in incidence of chronic renal glomerular disease,diabetes mellitus,hypertension accounted for 59.34%,28.57%,12.09%.The primary incidence of chronic glomerulonephritis was TC,TG,LDL-C,Lpa,HDL-C,and still high TG,Lpa and low HDL-C.The primary onset of diabetes and hypertension showed high TG,Lpa,and low HDL-C.4.There was a significant statistical correlation between hyperlipidemia and CRP level in CKD patients in the middle and late stages(P<0.05).There was no significant difference in the level of TC,TG,LDL-C and CRP in phase CKD3-5(P>0.05).The level of Lpa in the 3-5 phases was positively correlated with the level of CRP,of which 3(r=0.528,P<0.05),4(r=0.391,P<0.05),and 5(r=0.342,P<0.05).CKD4 and 5 phase HDL-C were negatively correlated with CRP levels,of which 4(r=-489,P<0.05),and 5(r=-0.646,P<0.05).5.There was no significant difference in CRP level between CKD patients and hypertension or diabetes mellitus(P>0.05).The difference was statistically significant in patients with or without heart disease(P<0.05).The level of CRP in the primary disease was significantly increased in the primary disease.4 Conclusion1.Dyslipidemia and micro inflammation are common in patients with chronic renal disease in the middle and late stages.The characteristics of dyslipidemia are the high level of TG,LPa and low HDL-C in CKD3-5 phase.And with the progression of renal function,hyperlipidemia is gradually evident.The high Lpa and low HDL-C levels affect the progression of renal function.Micro inflammation is mainly developed as the level of CRP gradually increases with the progression of renal function.2.The primary disease is diabetes and hypertension.It is significantly higher than that of TG,Lpa and low HDL-C level.The incidence of chronic glomerulonephritis is high TC,TG,LDL-C,Lpa level and low HDL-C level,but still high TG,Lpa and low level of HDL-C.3.There was a widespread inflammatory state in the middle and late stage of chronic kidney disease and hyperlipidemia.Lpa was positively correlated with CRP.In CKD4 and 5,HDL-C was negatively correlated with CRP level.4.In the middle and late stages of chronic renal disease,micro inflammatory factors have a predictive role in CKD complicated with CVD.