| Objective: To observe the clinical therapeutic effect of Ganshuang Granules combined with reduced glutathione in the treatment of chronic hepatitis B liver fibrosis.Methods: A total of 62 patients with chronic hepatitis B from the Department of Hepatobiliary and Pancreatic Medicine of the Second Hospital of Jilin University from August 2016 to December 2018 were enrolled.The patients were randomly divided into the liver-supplemented granule combined with reduced glutathione treatment group.The Ganshuang Granule treatment group consisted of 20 patients in the control group 1 and 20 patients in the control group with reduced glutathione alone.The experimental group was given 3 g/time and 3 times/day for the treatment of the liver.Glutathione 4 tablets/time,3 times/day combination therapy;control group 1 single liver granules,liver granules 3g/time,3 times/day treatment;control group 2 single-use reduced glutathione 4 Tablets/time,3 times/day treatment,1 course for 2 months.The recurrence of liver function was measured before and 2,4,and 8 weeks before treatment.The liver elasticity test was used to detect the changes of liver fibrosis in patients with chronic hepatitis B before and 4 and 8 weeks after treatment.At the same time,at the 2nd,4th and 8th week of treatment,the improvement of symptoms and signs was evaluated.Results: 1.Liver function recurrence in combination therapy group,Ganshuang granule group and glutathione group before and after treatment The liver function was evaluated throughout the course of treatment.Compared with the liver granule group and glutathione group,ALT,AST,TBIL and GGT were significantly lower than those of the control group at 2 weeks and 4 weeks after treatment,and the difference was statistically significant(P <0.05).The reduced of liver function indexes ALT,AST,TBIL and GGT in the combined treatment group was a significant decrease lower than that before treatment and in the liver granule group and glutathione group.The difference was statistically significant(P<0.05,P<0.05).There was no significant decrease in the decrease of liver function index between Ganshuang Granule group and glutathione group before treatment.The difference had no statistically significant(P>0.05).After the 4th week of treatment,the decrease of liver function index in the combined treatment group was a significant decrease lower than that in the liver granule group and glutathione group,the difference was had a 2.Huge statisticsignificant(P<0.05);liver granule group and glutathione group The liver function index was significantly lower than that before treatment,and the difference was a huge significant(P<0.05).At the end of treatment,the liver function indexes of each group returned to normal,and there was not had significant difference between the 3 groups(P>0.05).2.Improvement of general symptoms in each group before and after treatment The improvement of general symptoms(such as general malaise,loss of appetite,bloating,nausea,liver pain,etc.)in each group was evaluated before treatment and at 2,4,and 8 weeks of treatment.At 2 weeks of treatment,the improvement of general symptoms in the combined treatment group was significantly better than that in the pre-treatment group and the liver-supplemented group and the glutathione group,the difference was had a huge significant(p<0.05);the general symptom improvement in the combined treatment group at 4 weeks of treatment It was also significantly better than the Ganshuang Granule group and the glutathione group,the difference was had a huge significant(p<0.05);the general symptoms of the Ganshuang Granule group and the glutathione group were significantly better than before treatment,and the difference was had a huge significant.Significance;there was not had a huget difference in efficacy between the groups at 8 weeks of treatment(p>0.05).3.Improvement of liver elasticity analysis results before and after treatment The changes of liver elasticity(KPA)in patients with chronic hepatitis B liver fibrosis before and after treatment at 4 and 8 weeks after treatment showed that at 4 weeks of treatment,liver elasticity analysis,combined treatment group and liver granule group liver The elasticity value decreased,and the difference was not had a huge significant(p>0.05).There was no change in the glutathione group before and after treatment(p>0.05).At the end of one course of treatment,the decrease of liver elasticity in the combination group and the liver granule group was significantly lower than that in the pre-treatment and glutathione groups(P<0.05,P<0.05).There was no significant change in the end of the treatment of the glycopeptide group compared with before treatment,and the difference was not had a huge significant(P>0.05).Conclusion: 1.Ganshuang Granule combined with reduced glutathione in the treatment of patients with chronic hepatitis B liver fibrosis is better than the single drug group in improving patients' clinical symptoms,restoring liver function and anti-fibrosis.2.Ganshuang Granule can improve liver function and reduce liver elasticity(KPA).3.The effect of Ganshuang Granules combined with reduced glutathione on liver fibrosis in patients with chronic hepatitis B is more significant and worthy of clinical application. |
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