Effects Of Demedetomidine On Hemodynamics And Postoperative Nausea And Vomiting During Extubation

Objective: To investigate the effects of dexmedetomidine on hemodynamics and postoperative nausea and vomiting during extubation.Methods: Forty-eight patients who underwent elective surgery under general anesthesia(including breast and thyroid surgery)were divided into two groups according to the random number table: 17 patients in group A(normal saline group),who was treated with normal saline until extraction;17 patients in group B(dexmedetomidine group),who was treated with dexmedetomidine at a dose of 0.2?g·kg-1·h-1 until extraction.The systolic blood pressure,diastolic blood pressure,and heart rate were recorded at the time of before surgery,extubation,10 minutes after extubation,1 hour after extubation,and recorded VRS pain score and RASS sedation score at the time of extubation and 1 hour after extubation,and evaluation of agitation of extubation.Observed and recorded the number and severity of postoperative nausea and vomiting in three time periods after surgery(0~1h,1~6h,6~24h),and recorded the blood glucose at the time of after surgery,extubation,and 1 hour after extubation.Extubation time and adverse reactions with hypotension,bradycardia,and respiratorydepression were recorded.Results: The systolic blood pressure,diastolic blood pressure and heart rate of group B were lower than those of group A at the time of extubation and 10 minutes after extubation(P<0.05),The diastolic blood pressure at 1 hour after extubation was lower in group B than in group A(P<0.05).The RASS sedation scores at the time of extubation were statistically significant(P<0.05).There was no significant difference in the extubation time between the two groups(P>0.05).There was no significant difference in the incidence and severity of nausea and vomiting between the two groups at different time points(P>0.05);blood glucose was lower at the time of extubation in group B than in group A(P<0.05);no adverse reactions were observed in either group.Conclusion: Dexmedetomidine was used to after operation can alleviate extubation stress.