The Study Of Correlation Between Cognition Function And MRI Visual Rating Of Brain Structure In AD And MCI Patients

ObjectivesTo analyze the changing characteristics of cognitive function and MRI visual rating in patients with AD and MCI,and to explore the correlation between them.MethodsWe collected 35 patients with MCI and 85 patients with AD from Department of Neurology and Neuroscience Center,the First hospital of Ji Lin University between October 2017 and December 2018.And 35 healthy control subjects were recruited into the group according to the inclusion criteria.According to the grading of Clinical Dementia Rating(CDR),the patients were divided into four groups: MCI group(CDR = 0.5),mild AD group(CDR = 1.0),moderate AD group(CDR = 2.0),severe AD group(CDR = 3.0).We collected the relevant data of all the patients,including general clinical data,neuropsychological assessment and 3.0T head MRI.MTA,GCA and PA visual rating scales were performed by the same radiologist.Use SPSS20.0 software to carry out the statistical analysis of data.Results1.There were no statistical differences in gender,education level and left or right-handedness among the five groups.2.The MMSE total scores,time and location orientation,memory and recall ability of the AD group were significantly different from the normal control group and the MCI group(P<0.05).Except for naming,attention and language,the total scores or other sub-items of Mo CA in AD patients were significant differences from the normal control group and the MCI group(P<0.05).There were significant differences in the scores of Mo CA delayed recall ability and CDR scale between MCI patients and normal controls(P<0.05).There were no significant differences in the scores of ADL scale between MCI patients and normal controls.3.For MTA,GCA and PA visual rating scales,there were significant differences between AD patients and normal controls(P < 0.05),but there was no significant difference between MCI patients and normal controls.4.The left and right side scores and total scores of MTA and GCA visual rating scales in mild,moderate and severe AD patients were significantly different from those in MCI patients(P < 0.05).The left and right side scores and total scores of PA visual rating scales in mild AD patients were not significantly different from those in MCI group.The right side scores and total scores of PA visual rating scales in moderate AD patients were not significantly different from those in MCI group.The left and right side scores and total scores of PA visual rating scales in severe AD patients were significantly different from those in MCI patients(P < 0.05).5.All patients were divided into three groups according to age—40-65 years old group,66-75 years old group and 76-85 years old group.The results showed that there were significant differences in left and right side scores and total scores of MTA and GCA visual rating scales in different age groups(P < 0.001).And the left and right side scores and total scores of MTA and GCA visual rating scales were positively correlated with age.There was no significant difference in the left and right side scores and total scores of PA visual rating scales between different age groups.There was no correlation between the PA visual rating scales and age.6.There was no correlation between MTA,GCA,PA visual rating scales and neuropsychological assessment in MCI patients.7.The left and right side scores and total scores of MTA,GCA,PA visual rating scales in AD patients were correlated with ADL,CDR,MES,Mo CA and MMSE scales.The left and right side scores and total scores of MTA,GCA,PA visual rating scales were positively correlated with ADL,CDR scales.The left and right side scores and total scores of MTA,GCA,PA visual rating scales were negatively correlated with MES,MMSE and Mo CA scales.8.Compared with MTA,GCA visual rating scales,there was poor correlation between PA visual rating scales and neuropsychological assessment in AD patients.9.MTA visual rating scales had the strongest correlation with MES scale,followed by MMSE scale.And GCA visual rating scales had similar correlation with MES,Mo CA and MMSE scales.Conclusions1.Multiple cognitive areas of AD patients are impaired,including memory,orientation,computational power,visual space and executive ability.While there is no significant change in the naming ability and language ability of early AD patients.The main manifestation of MCI patients in cognitive dysfunction is that the ability of delayed recall is impaired,and its daily living ability is normal.2.With the increase of dementia degree,cognitive function of patients declines significantly,and their daily living ability is declining,and their atrophy of brain structures,such as,medial temporal lobe,global cortical and posterior cortical is obvious.3.For AD patients,MTA,GCA and PA visual rating scales have good diagnostic performance.And they can be combined with neuropsychological assessment to diagnose AD.4.For MCI patients,the changes of brain structure on MRI are not obvious yet.And neuropsychological assessment is still a sensitive diagnostic indicator.