| ObjectivesTo construct cognitive behavioral intervention for alleviating the fear of progression with Non-Hodgkin lymphoma patients,and to explore its application effect on alleviating the fear of progression,improving the level of hope and improving the quality of life.By defining the effect of cognitive behavioral intervention on alleviating the fear of progression,we hope to provide reference for the follow-up intervention research in China.Methods1.This research is a quasi-experimental study.Non-Hodgkin's lymphoma patients who met the inclusion criteria of this study were selected from the First Affiliated Hospital of Zhengzhou University.Two courtyards were randomly divided into intervention group and control group by coin flipping method.The intervention group was given cognitive behavioral intervention once a week for 6 weeks,45~60minutes each time.The control group received only one lecture about lymphoma knowledge,followed by routine nursing.2.Data were collected in the follow time points: pre-intervention,postintervention,1 and 3 months post intervention.The evaluation tools were questionnaires of demographic data,Fear of Progression Questionnaire-Short Form(FoP-Q-SF),Herth Hope Index(HHI)and Functional Assessment Cancer Therapy-Lymphoma(FACT-Lym)to evaluate the intervention effect.3.Intention-to-treat analysis(ITT)was used to evaluate the effect in order to reduce the impact of bias on the results,SPSS software version 21.0 for data collation and analysis.Using frequency,rate,and percentage to describe the demographic data;using mean,standard deviation to describe quantitative data;using generalized estimation equation to analyze the trend of FoP-Q-SF,HHI,FACT-Lym scores at each time point.All the tests showed significant difference with P<0.05.The level of alpha was 0.05.Results1.A total of 83 patients were included in this study,41 and 42 in the intervention group and control group.However,3 patients of lost in the intervention group and 5 patients in the control group,with a total drop-out rate in 9.64%.According to the data processing method of ITT,a total of 81 patients were included in the result analysis,41 in the intervention group and 40 in the control group.The age of the intervention group was(45.71±14.06)and that of the control group was(46.69±12.32).At baseline,the total scores of FoP-Q-SF,HHI and FACT-Lym scales and their dimensions were not significantly different between the two groups(P >0.05).2.The changes of FoP-Q-SF scores in the pre-intervention,post-intervention,1and 3 months post intervention were analyzed by using generalized estimation equation.The results showed intervention group had significant group(Wald = 36.243,P < 0.001),time(Wald = 109.584,P < 0.001),and group-by-time interaction(Wald =68.785,P < 0.001).There was statastical significance of FoP-Q-SF score between the pre-intervention with the post-intervention,1 and 3 months later(P < 0.05).3.The changes of HHI scores in the pre-intervention,post-intervention,1 and 3months post intervention were analyzed by using generalized estimation equation.The results showed intervention group had significant group(Wald = 16.190,P <0.001),time(Wald = 35.669,P < 0.001),and group-by-time interaction(Wald =44.063,P < 0.001).There was statastical significance of HHI score between the pre-intervention with the post-intervention,1 and 3 months later(P < 0.05).4.The changes of FACT-Lym scores in the pre-intervention,post-intervention,1and 3 months post intervention were analyzed by using generalized estimation equation.The results showed intervention group had significant group(Wald = 29.525,P < 0.001)and time(Wald = 82.396,P < 0.001),and group-by-time interaction(Wald= 43.936,P < 0.001).There was statastical significance of FACT-Lym score between the pre-intervention with the post-intervention,1 and 3 months later(P < 0.001).5.The results of ITT analysis showed that the group-by-time interaction,time and group effect of FoP-Q-SF,HHI and FACT-Lym had statistical significance(P <0.001),indicating that the above conclusions were stable.ConclusionCompared with routine nursing,cognitive behavioral intervention for alleviating the fear of progression is effective with Non-Hodgkin lymphoma patients,improve the level of hope,and have a positive effect on improving the quality of life.The intervention program is operable and can be promoted in cancer patients. |
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