Effects Of Oxycodone And Dezocine On Anesthesia Recovery In Patients Undergoing Liver Cancer Resection

Objective To observe the effects of oxycodone and dezocine on anesthesia recovery in patients with liver cancer resection,and to compare the advantages and disadvantages of both in postoperative recovery.Methods Sixty patients who underwent elective hepatic resection of liver cancer at the Affiliated Tumor Hospital of Guangxi Medical University from March 2018 to December 2018 were selected.The patient selection criteria were:age 18-65 years old,gender is not limited,BMI 18-30kg/m~2,ASA Grade I-II,Child-Pugh score A,no significant other systemic complications.Patients were randomized into three groups according to the random number table,with 20patients in each group.The anesthesia induction and maintenance were performed in the same manner in each group of patients.Group Q,group D,and group C were intravenously injected with oxycodone hydrochloride 0.1 mg/kg,dezocine 0.1 mg/kg,and fentanyl 2?g/kg,15 minutes before the end of the operation.All anesthetics are stopped after the seam is finished.Each group of patients received routine intravenous infusion of 5 mg tropisetron to stop vomiting,after operation.The preoperative and postoperative BIS values were recorded;the time from the stop pumping of the anesthetic to the patient's spontaneous respiration recovery time,the recovery time and the extubation time were recorded.when the patient entered the room(T0),the time of surgery(T1),and 10 min after blink(T2),at the time of extubation(T3),5 min after extubation(T4),after 10 min(T5),after 30 min(T6)and after 1h(T7),2 h after extubation(T8)HR,SPO2,MAP;record VAS score,Steward score,modified Aldrete score,Ricker sedation-incitement score from T2 to T8.The number of cases requiring remedial analgesia was recorded;the length of the surgical incision,the time of surgery,the amount of drug and fluid were recorded;and the occurrence of adverse reactions was recorded.Result 1.In terms of respiratory recovery time,blink time,offline time,and extubation time,the group Q was significantly shorter than the group C(P<0.05),and the group D had short time except for the blink time and C.In group C(P<0.05).There was no significant difference in respiratory recovery time,blink time,offline time,and extubation time between the D and Q groups.2.In terms of VAS score,the group Q was significantly smaller than the group C at each time(P<0.05);there was no significant difference between the group D and the group C at each time(P>0.05).In the D and Q comparisons,the group Q at T2,T3,T5,T6,and T7 was significantly smaller than the D group(P<0.05).3.In the Steward score,the group Q was higher than the group C at the time of T3-T6(P<0.05);there was no significant difference between the group D and the group C at each time(P>0.05);In the comparison of D and Q groups,the group Q at T2 and T4-T6 was significantly higher than the D(P<0.05).In the modified Aldrete score,the group D score was observed at T5 time was smaller than the group C(P<0.05);The scores of group Q at T2-T6 were higher than those of group D(P<0.05).In the Ricker sedation-incitement score,the group Q was higher than the group C at T4 and T5(P<0.05);the group D was higher than the group C at T2(P<0.05),and the group D was lower than the group C at T6 and T7(P<0.05),The group Q was lower than the group D at the time of T2(P<0.05),and the group Q was higher than the group D at the time of T3-T7(P<0.05)4.The incidence of adverse reactions was not significantly different between group Q and group C(P>0.05);group D was significantly higher than group C and group Q(P<0.05).5.the comparison of remedial analgesia,group Q and group D were less than group C,there were statistical differences(P<0.05);There was no significant difference between D and Q groups(P>0.05).Conclusion Intravenous injection of 0.1 mg/kg oxycodone before the end of surgery can improve anesthesia recovery in patients undergoing liver cancer resection without increasing the incidence of complications;intravenous injection 0.1 mg/kg Dizocine before the end of surgery did not improve anesthesia recovery,and the incidence of postoperative agitation increased significantly.