Analysis Of Clinical Characteristics Of Kawasaki Disease With Liver Damage In Children

Objective Using retrospective analysis,the clinical manifestations and laboratory findings of 167 children with Kawasaki disease were analyzed to understand the significance of liver damage in the clinical course of Kawasaki disease,in order to provide some help to improve the diagnosis and treatment of the disease.Methods A total of 167 children with Kawasaki disease who were diagnosed in the First Affiliated Hospital of Guangxi Medical University from January 2013 to September 2018 were enrolled,including 72 patients with liver damage and 95 patients with normal liver function.The general situation,clinical manifestations,laboratory test results,etc.were compared and analyzed,and the risk factors of liver function damage in children with Kawasaki disease were analyzed.Results 1.Comparison of general conditions:Age and gender analysis:167 children with Kawasaki disease had an onset age of 2 months to 13 years and 2 months,with an average age of 2.73 years,119 males and 48 females,with a male to female ratio of 2.48:1.?1 year old 29.94%(50/167),?2 years old23.95%(40/167),?3 years old 16.17%(27/167),?4 years old 11.98%(20/167),?5 years old 8.38%(14/167),>5 years old 9.58%(16/167),the incidence of male and female in different age groups was not statistically significant(P>0.05).There were 93 cases of complete Kawasaki disease(55.69%,93/167)and 74 cases of incomplete Kawasaki disease(44.31%,74/167),and in different age of these two groups was statistically significant(P<0.05).There were statistically significant differences between the normal liver function group and the damage group in the age group and the mean age(P<0.05).There was no significant difference in gender between the normal liver function group and the injured group(P>0.05).The number of cases in the normal liver function group and the lesion group was statistically significant in the comparison of cKD and iKD(P<0.05).2.Comparison of main clinical manifestations:The incidence comparison of major clinical manifestations in the normal liver function group and the lesion group,conjunctival hyperemia was statistically significant in both groups(P < 0.05).There was a statistically significant comparison in the number of fever days between the normal liver function group and the injured group(P value <0.05).There was a statistically significant difference in the number of fever days of cKD and iKD in the normal liver function group(P<0.05).There was no significant difference in the number of fever days of cKD and iKD in the liver function damage group(P>0.05).3.Comparison of laboratory indicators:Compared with the laboratory results of the liver function normal group and the injury group,the HB in the liver function damage group was lower than that in the normal group,while the WBC,N,CRP,and ESR were higher than the normal group.The two groups were statistically significant(P<0.05).4.Correlation analysis:Albumin(ALB)was negatively correlated withCRP and ESR(correlation coefficient r=-0.507,r=-0.472,respectively),Alanine aminotransferase(ALT),?-glutamyltranspeptidase(Gamma glutamyl transpeptidase(GGT)was positively correlated with CRP and ESR(the correlation coefficients of ALT,CRP and ESR were r=0.272,r=0.241;the correlation coefficients of GGT and CRP,ESR were r=0.424,r=0.429,respectively).5.Comparison of coronary artery damage(CAL):There was no significant difference between the normal liver function group and the injured group comparison of abnormalities in coronary arteries(P>0.05).There were no statistically significant differences in the left and right coronary lesions between the normal liver function group and the lesion group(P>0.05).There was no statistically significant difference in the degree of CAL damage between the normal liver function group and the lesion group(P>0.05).6.Analysis of risk factors:The results of binary logistic regression analysis showed that older children,elevated CRP and increased ESR were risk factors for liver function damage in Kawasaki disease.Conclusion 1.This data shows that complete Kawasaki disease is more common in children aged 2-3 years,and incomplete Kawasaki disease is more common in infants under 1 year old;2.There is no significant correlation between liver damage and Kawasaki disease coronary lesions;3.Older children,elevated CRP and increased ESR are risk factors for liver function damage in Kawasaki disease.