The Prognostic Value Of Platelet/Lymphocyte Ratio In Patients With Nonmuscular Invasive Bladder Cancer

Objective: To evaluate the prognostic value of platelet/lymphocyte ratio(PLR)in patients with nonmuscular invasive bladder cancer(NMIBC).Methods: 105 patients with NMIBC who met the inclusion criteria from June 2012 to December 2015 were retrospectively analyzed.PLR was calculated according to preoperative blood routine results.The patients were divided into low value group(PLR < 110)50 cases and high value group(PLR?110)55 cases by median method.The survival time and outcome of the two groups were compared during the follow-up period.The criteria for calculating survival time were: from discharge date to death or follow-up date(5 years after operation),to explore the effect of PLR on the prognosis of patients with NMIBC.Cox proportionalhazard model was used to analyze multiple factors to explore whether PLR was an independent risk factor for patients with NMIBC.Result:1.There was no significant difference in age,sex and BMI between the two groups.There was no significant difference in tumor grade,size,number,secondary resection ratio,postoperative intravesical instillation chemotherapy,recurrence rate and tumor progression between the two groups.The mean survival time of the low-value group was 49.36(±8.95)5 months,and the median survival time was 51 months.The median survival time of the high-value group was 34.85(±9.46)4 months,and the median survival time was 34 months.By comparison,the survival time of low PLR group was higher than that of high PLR group,and the difference was statistically significant(P < 0.05).2.Univariate analysis indicated that variables with statistical significance(P < 0.05)were included in Cox model for multivariate analysis.After correcting age,sex and BMI,the results showed that preoperative high PLR(P < 0.05)was an independent risk factor for survival time of NMIBC patients treated with TURBT.Conclusion:1.The higher PLR of NMIBC patients before operation may indicate that the survival time after operation is shorter.2.Preoperative PLR is expected to be a prognostic indicator ofNMIBC patients treated with TURBT,and has important clinical value.