Comparison Of Clinical Characteristics Of Pseudomonas Aeruginosa Or Candida Albicans And Their Co-Infection With Ventilator Associated Pneumonia

Objective: To analyze the clinical features of patients with ventilator-associated pneumonia(VAP),who were infected with Candida albicans(C.albicans),Pseudomonas aeruginosa(P.aeruginosa)and their co-infections.To compare and analyze for their different characteristics.Methods: To collect the clinical data of 46 patients with VAP who met the diagnostic criteria in the First Affiliated Hospital of Guangxi Medical University from January 1,2016 to December 31,2018,who was infected with C.albicans,P.aeruginosa and their co-infections.It was summarized and analyzed retrospectively by using statistical methods.Results: 1.There were four common underlying diseases in 46 patients with VAP,including hypertension(65.2%),diabetes(28.3%),heart disease(26.1%),and cerebral infarction(15.2%),which were no significant difference among the three groups(p>0.05).2.The time of staying in the ICU and using the ventilator were significantly less in the C.albicans group than in the P.aeruginosa group(p<0.05,respectively).3.It had a higher incidence with P.aeruginosa infection and co-infection caused by tracheotomy,than with C.albicans infection(p < 0.05).4.After the occurrence of VAP in 46 patients,the total number of white blood cells,adenosine transferase,serum creatinine and G were higher than those before VAP,while albumin was lower than before.There was significant difference(p<0.05).5.In the comparison among the three groups after the occurrence of VAP,it was showed that the total number of leukocytes in group C.albicans was higher than that in the other two groups,while the G test value in group C.albicans was lower than that in the co-infection group(p < 0.05).6.Common imaging findings in patients with VAP among three groups were included patchy,flaky,cord-like,pleural effusion,atelectasis and air bronchial signs,but no significant difference(p>0.05).7.There was no statistically significant difference in prognosis among the three groups(?2=2.87,p=0.26).However,the co-infection group had a higher rate of exacerbation than the other two groups.Conclusions: 1.It suggests that the most common underlying diseases are hypertension,diabetes,and heart disease among three groups.2.It is showed that the time of staying in the ICU and using the ventilator are significantly less in the C.albicans group than in the P.aeruginosa group.3.It is little helpful to use G test,GM test,PCT and CRP to judge the infection with C.albicans,P.aeruginosa or their co-infection.4.It suggests that tracheotomy may be one of the reasons for increasing P.aeruginosa infection and co-infection,as it is showed that the incidence is higher with P.aeruginosa infection and co-infection than that with C.albicans infection.5.It also shows on obviously difference in the imaging findings of chest CT among the three groups.6.Although the deterioration rate of the three groups of VAP patients was not statistically significant,it could tend to go up in the co-infected group compareto the other two groups.