| Background: Acute myocardial infarction is a serious disease that threatens human life and the leading cause of cardiovascular death in the worldwide.It is a serious clinical event caused by sudden rupture of atherosclerotic plaque.Numerous researches confirmed that the occurrence of acute myocardial infarction is associated with chronic inflammation,lipid accumulation,vascular endothelium injury and dysfunction.Silent information regulator(SIRT)6 belongs to histone deacetylase,and has three kinds of enzyme activities: ADP ribosyltransferase,histone deacetylase,long-chain aliphatic groups that hydrolyze lysine residues.It also plays a role in DNA repairment,maintenance of telomere chromatin,inflammation,lipids and glucose metabolism.The studies related SIRT6 in cardiovascular diseases mainly focus on cardiac hypertrophy,myocardial fibrosis,and heart failure.There are few clinical studies showed the effect and mechanisms of SIRT6 on myocardial infarction and ischemia-reperfusion injury.Objective: Exploring the clinical significance of SIRT6 in patients through detecting the expression of SIRT6 in serum of patients with acute myocardial infarction,and further improving the theoretical system of the molecular mechanism of the occurrence and development of acute myocardial infarctio.Methods: Patients with acute myocardial infarction who underwent emergency PCI within 12 hours were enrolled in the acute myocardial infarction group from August 2018 to November 2018.Patients with angina pectoris who diagnosed in the Department of Cardiology of our hospital were enrolled in the angina pectoris group.All patients were divided into 4 groups according to with or without diabetes: acute myocardial infarction with diabetes group(group A),acute myocardial infarction without diabetes group(group B),angina pectoris with diabetes group(group C),angina pectoris without diabetes group(GroupD).The subjects who were included in the physical examination center of our hospital were selected as healthy control(Group E).Fasting blood was collected from the enrolled patients next day.The serum levels of SIRT6 were detected by ELISA.The baseline data of blood biochemistry were collected.All data was analyzed by SPSS24.0.Results:1.171 patients were enrolled in the study.There was no significant difference in age among three groups,and there was a significant difference in gender(p=0.05),which was statistically significant.There was no significant difference in age,history of cerebral infarction,and arrhythmia in four subgroups.There was difference in gender(p=0.011),history of hypertension(p=0.005),and history of myocardial infarction(p=0.002).And the difference has statistical significance.2.Serum SIRT6 levels in patients with acute myocardial infarction were significantly lower than those in healthy controls(p=0.019)and angina pectoris(p=0.019).The difference was statistically significant.SIRT6 level in the serum of the four subgroups(1.89±0.85,4.34±2.52,3.80±1.84,4.48±1.02,p=0.000)was analysed according to ELISA,and the difference was statistically significant.3.Correlation analysis: SIRT6 level was negatively correlated with NT-proBNP(r=-0.371,p=0.00),TNI(r=-0.307,p=0.002),glycosylated hemoglobin(r=-0.404,p=0.000),procalcitonin(r=-0.380,p=0.003),alanine aminotransferase(r=-0.190,p=0.000),aspartate aminotransferase(r=-0.162,p=0.000),serum amyloid(r=-0.249,p=0.011),lactic acid Dehydrogenase(r=-0.258,p=0.006),LDH isoenzyme(r=-0.284,p=0.003),and hydroxybutyrate deaminase(r=-0.268,p=0.005).Conclusion: Serum SIRT6 level in patients with acute myocardial infarction was significantly lower than both healthy people and angina pectoris.Serum SIRT6 level in patients with acute myocardial infarction and diabetes were significantly lower than those without diabetes,and significantly lower than those with or without angina pectoris.SIRT6 may affect the occurrence of acute myocardial infarction by regulating the inflammatory response and lipid metabolism in patients with acute myocardial infarction. |
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