Multiple Factors Of Delayed Encephalopathy In Acute Carbon Monoxide Poisoning Logistic Regression Analysis

Objectives:For patients with acute carbon monoxide poisoning(ACMP)with a history of coma,the risk factors for acute carbon monoxide poisoning delayed encephalopathy(DEACMP)were studied and analyzed to provide a theoretical basis for preventing the occurrence of DEACMP.Methods:According to the diagnostic criteria and exclusion criteria,a total of 233patients with acute carbon monoxide poisoning who had a history of coma from January2013 to March 2017 were collected from the emergency department of the Affiliated Hospital of Hebei University of Engineering.The clinical data of the subjects during the hospital were collected.Follow-up records(patients within 3 months of discharge)were divided into DEACMP group(57 cases)and non-DEACMP group(176 cases)according to the change of condition.The independent data t-test was used for the comparison between the data and the normal and the homogeneity of the variance.The non-parametric rank sum test was used for the unsatisfactory;the x~2 test was used for the comparison between the count data groups.Logistic stepwise regression analysis was used to analyze the influencing factors of delayed encephalopathy.P<0.05 was statistically significant.Finalize the ranking of risk factors and risk levels for DEACMP.Results:1.In the non-parametric rank sum test,the difference of GCS scores was statistically significant.There was no significant difference in age,lactate,D-dimer and carboxyhemoglobin.In the x~2 test,the differences in mental stimulation,coma time,hyperbaric oxygen frequency,and head CT/MRI were statistically significant.There was no significant difference in gender,hypertension,and diabetes.2.In multivariate logistic regression analysis,mental stimulation,coma time,GCS score,and hyperbaric oxygen frequency were independent influencing factors of DEACMP.The influence of the above four risk factors on DEACMP was mental stimulation>coma time>GCS score>hyperbaric oxygen frequency.3.The risk of developing DEACMP in patients with mental stimulation is 5.050 times that of patients without mental stimulation.4.The risk of DEACMP in ACMP patients with coma time?24h is 3.807 times that of patients with coma<24h.5.The risk of developing DEACMP in ACMP patients with GCS?5 is3.654 times that of patients with GCS>10,and the risk of developing DEACMP inACMP patients with 5<GCS?10 is 2.864 times that of patients with GCS>10.6.The number of hyperbaric oxygen?10 times is the protective factor for DEACMP.The risk of DEACMP in ACMP patients with hyperbaric oxygen<10 times is 2.977 times that of patients with hyperbaric oxygen?10 times.Conclusions:1.Mental stimulation,coma time,GCS score,hyperbaric oxygen frequency,and head CT/MRI are risk factors for developing DEACMP in ACMP patients with a history of coma.2.Mental stimulation,coma time,GCS score,hyperbaric oxygen frequency is an independent risk factor for DEACMP in ACMP patients with a history of coma.The degree of influence on DEACMP is mental stimulation>coma time>GCS score>hyperbaric oxygen frequency.