| Objectives:Skin basal cell carcinoma is one of the most common skin tumors,accounting for 80% of non-melanoma.Occurs in the exposed parts of the head,face,neck,etc.Studies have shown that in addition to ultraviolet light,the cause of the disease is also related to immunosuppression,scars,and hereditary diseases.In recent years,the incidence of the disease is on the rise.It can be transferred to cartilage,bones and important organs through blood vessels and lymphatic vessels.The metastasis rate is 0.0028%-5%,which brings serious physical and mental burden to patients.At present,the pathogenesis of the disease and new treatment methods have gradually attracted the attention of researchers.It is worthy of continuing research by clinical medical workers,which is expected to provide a new theoretical basis for the pathogenesis of BCC.Heat shock proteins(HSPs)are a family of highly conserved proteins that are induced by various stressors and have a function of maintaining protein stability and promoting cell survival.They are ubiquitous in organisms.According to the molecular weight,it is divided into five major families: HSP,HSP60,HSP70,HSP90 and HSP100.Recent studies have shown that heat shock proteins are involved in the regulation of multiple signaling pathways and cell cycle,and play an important role in carcinogenic signal transduction,apoptosis,metastasis,etc.and will soon become a new set of tumor markers.Among them,HSP60 and HSP90 are the two most common types of heat shock proteins in mammals,which play an important role in the signal transduction process that promotes tumor cell proliferation and inhibits apoptosis.Many basic and clinical experiments have shown that high expression or ectopic expression of HSP60 and HSP90 is closely related to tumorigenesis,development and biological behavior.In this study,the expression of HSP60 and HSP90 in basal cell carcinoma and normal epidermal tissue was detected by immunohistochemistry.The expression levels of HSP60 and HSP90 in basal cell carcinoma of the skin and the relationship between them were investigated.Shock protein-related inhibitors provide new therapeutic targets for the clinic.Methods:Collecting 35 cases of basal cell carcinoma tissue and 10 cases of normal skin tissue of the dermatology department of Affiliated Hospital of Hebei University of Engineering in 2017-2018,and detecting HSP60 and HSP90 in basal cell carcinoma tissues and normal tissues of cancer by immunohistochemical staining.The expression level of HSP60 and HSP90 in basal cell carcinoma of the skin and the correlation between HSP60 and HSP90 expression in normal tissues of the peri-tumor and the correlation between the two,and whether the skin can be treated by the inhibitor of heat shock protein Basal cell carcinoma.Results:The expression of HSP60 in basal cell carcinoma was significantly higher than that in normal tissues(?2=11.048,P<0.05).HSP60 was mainly expressed in the cytoplasm of cancer tissues,which was light yellow to brown homogeneous powdery or granular material,positive.The cells showed a diffuse distribution of focal lesions,mostly in cyst-like,adenoid-like differentiated tumors.The expression of HSP90 in basal cell carcinoma was significantly higher than that in normal tissues(?2=3.401,P<0.05).Most of HSP90 was expressed in the cytoplasm of cells,partially in the nucleus,and it was light yellow to yellow homogeneous powder or granular.Substance,positive cells were diffusely distributed in spots.There was no correlation between HSP60 and HSP90 expression in basal cell carcinoma of the skin(r S=-0.250,P>0.05)?Conclusions:HSP60 and HSP90 may be involved in the occurrence and development of basal cell carcinoma.The expression level of HSP60 in basal cell carcinoma is different from that of HSP90.It is speculated that HSP60 and HSP90 mediate tumorigenesis and development through different pathways.There is no correlation between the expression levels of HSP60 and HSP90 in basal cell carcinoma. |
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