The Expression Of COX-2, HIF-1α And The Correlation With Angiogenesis In Cutaneous Carcinoma

Background and objectiveCutaneous squamous cell carcinoma (SCC) and basal cell carcinoma(BCC) which are common skin malignant tumors all belong to the non-melanoma skin cancer (NMSC). Like other malignant tumors, their transformation is also a multistage, progressive process. Traditionally, it is regarded as a result with multimutation of genes, including such as mutation of oncogenes, inactivation of tumor suppressor genes and unbalance of apoptosis. However, tissue cells once transform into malignant cells, theirs bio-behaviour also change into continuous and unlimited proliferation, and finally form a tumor. The continuous proliferation of tumor cells will lead to the regions of hypoxia. Then, it is needed to form new blood vessles to prodvide enough blood and take away the metabolite. With the further researching, people found that cyclooxygenase-2 (COX-2) and hypoxia-inducible factor-1α (HIF-1α) play key roles during angiogenesis.It is well known that COX-2 catalyze the rate-limiting step of converting arachidonic acid (AA) to prostaglandin. It can promote angiogenesis through a few ways. HIF-1α is now known as the unique transcription factor under hypoxia conditions. VEGF gene shows different levels of HIF-1-dependent hypoxia-inducible expression which include up-regulated translational efficiency and mRNA stability. VEGF, a key factor in tumor angiogenesis, is also one of the most efficient factors. Therefore, it will be helpful to elucidate the mechanism of SCC and BCC by...