Study On The Relationship Between Cobalt,Selenium And Chromium Concentration In Maternal Umbilical Cord Blood And Fetal Growth And Development

Objective: To investigate the concentration of cobalt,selenium and chromium in the maternal and fetal bodies of the general population,to explore the influencing factors and the influence of cobalt,selenium and chromium in fetal umbilical cord blood,especially the relationship between the level of cobalt,selenium and chromium in umbilical cord blood and fetal growth.Method:(1)Research objectives:150 parturients were randomly selected from October 2006 to March 2007 in the Department of Obstetrics and Gynecology,967 Hospital of the People's Liberation Army of China.A total of 139 pairs of mothers and infants were matched.(2)Self-made questionnaires: the pregnant women included in the study were surveyed by "health questionnaire",which included:(1)the living and working environment of pregnant women;(2)the basic information of pregnant women included:age,weight,height,education,income;(3)the basic information of pregnant women:diet,emotional changes,active or passive smoking,pregnancy complications,etc.(3)fetal development indicators: neonatal growth and development parameters were collected at birth,including weight,length,head circumference and chest circumference.(4)Blood sample collection and determination: 3 ml of venous blood was taken from pregnant women when they were admitted to hospital,placed in anticoagulant vacuum blood vessel collection,shaking and mixing immediately,placed in refrigerator for cryopreservation;3 m L of cord blood was taken for cryopreservation when neonates were delivered,and the concentration of cobalt,selenium and chromium in mother's cord blood was detected by inductively coupled plasma mass spectrometry(ICP-MS).(5)Statistical methods: Data were analyzed by SPSS24.0 software.One-way variance,multiple linear regression analysis,t-test and Pearson correlation analysis were used for statistical analysis.P < 0.05 was statistically significant.Result:(1)Single factor analysis of cobalt,selenium and chromium concentration in maternal blood among different factors.The blood cobalt content of pregnant women with junior high school education,low income,occupation as workers or unemployed,drinking water as well water,no passive smoking,exposure to harmful factors(including noise,electronic radiation,biochemical agents),large chimneys and main roads near their homes increased significantly(P < 0.05).However,emotions,recent decoration and daily milk consumption had no effect on cobalt content in pregnant women(P > 0.05).The serum selenium content of pregnant women with happy mood,no passive smoking and drinking milk every day increased significantly(P < 0.05).However,educational background,occupation,income and other factors had no effect on the selenium content of pregnant women(P > 0.05).The blood chromium content of pregnant women with junior high school education,occupation as workers or unemployed,low income,drinking water as well water,exposure to harmful factors,large chimneys near their homes,recent decoration and main roads of transportation increased significantly(P < 0.05).However,emotions,passive smoking and daily milk consumption had no effect on chromium content in pregnant women(P > 0.05).(2)Analysis of correlation between cobalt,selenium and chromium content in maternal umbilical cord blood and infant indicators.There was a positive correlation between cobalt,selenium and chromium in maternal blood and umbilical cord blood(P < 0.05).There was no correlation between the cobalt content in umbilical cord blood and body weight,body length,head circumference and chest circumference(P > 0.05).The selenium content in cord blood was positively correlated with body weight(P< 0.05),but not with body length,head circumference and chest circumference(P >0.05).Chromium content in cord blood was negatively correlated with body weight,body length and chest circumference(P < 0.05),but not with head circumference(P > 0.05).Conclusion:(1)Concentrations of cobalt,selenium and chromium in maternal blood were related to environmental factors and diet.(2)Concentrations of cobalt,selenium and chromium in maternal blood affect the concentrations of cobalt,selenium and chromium in umbilical cord blood.(3)Concentrations of cobalt,selenium and chromium in cord blood were correlated with fetal growth parameters.(4)The levels of cobalt,selenium and chromium in maternal umbilical cord blood may affect fetal growth and development.