Non-motor Symptoms Of Parkinson's Disease And Its Correlation With Serum Lipids

Objectives: 1.The incidence and clinical factors of non-motor symptoms(NMS)in Parkinson's disease;2.Characteristics of serum lipids in patients with Parkinson's disease;3.Analysis of the correlation between NMS(cognitive dysfunction,anxiety and depression,sleep disorders,autonomic dysfunction)in Parkinson's disease and serum lipids.Methods: A prospective study was conducted to collect 123 patients with Parkinson's disease who were admitted to The Second Affiliated Hospital of Dalian Medical University from August 2017 to December 2018.Another 123 healthy subjects were selected as the control group.Collect basic information and lipid profiles of total Parkinson's disease group and healthy control group(Total cholesterol TC,Triglyceride TG,High density lipoprotein cholesterol HDL-C,Low density lipoprotein cholesterol LDL-C,Apolipoprotein A1 ApoA1,Apolipoprotein B ApoB),and a NMS scale assessment of patients with Parkinson's disease.1.Assess the incidence of NMS in Parkinson's disease by the Parkinson's Disease Non-Sports Screening Scale(NMS Quest),and analysis of the correlation between the frequency of NMS and clinical factors such as patient age,gender,duration of disease and disease severity.2.Comparison of significant differences in serum lipids between Parkinson's disease group and control group.3.Through the Spearman correlation analysis to explore the correlation between serum lipids and NMS scale scores,such as: Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA),Mini-mental State Examination(Mini-mental State Examination,MMSE),Pittsburgh sleep quality index(PSQI),The scale for outcomes in PD for autonomic symptoms(SCOPA-AUT),etc.4.According to MMSE,HAMA and HAMD scores,NMS were divided into cognitive disorder group and cognitive normal group,anxiety group and non-anxiety group,depression group and non-depression group.The general data and blood lipid levels of the two groups were compared to determine whether the blood lipids were independent risk factors for a certain NMS.Results: 1.The incidence of NMS in 123 patients with Parkinson's disease was 95.9%.The highest incidence was autonomic neurological symptoms(95.9%),followed by sleep disorders(60.1%),cognitive dysfunction(54.4%),neuropsychiatric disorders(40.6%),and sensory disturbances(26.0%).There was a significant correlation between the frequency of NMS and age,duration of disease and severity of illness(p < 0.05).2.There were no significant differences in the basic data of 123 patients with Parkinson's disease and 123 healthy controls.The differences of age,gender,basic medical history and education level were not significantly different between the two groups(p > 0.05).The serum lipid level of Parkinson's disease group was generally lower than that of healthy control group,and TC,LDL-C and ApoA1 were significantly lower than the control group,the difference was statistically significant(p < 0.05).3.According to Spearman correlation analysis,there was a significant positive correlation between MMSE score and total lipid index;there was a significant negative correlation between HAMD and TC,LDL-C,ApoA1 and ApoB;there was a significant negative correlation between HAMA score and TC and TG;there was a significant negative correlation between SCOPA-AUT and TG(p < 0.05).4.(1)The general data and lipid profile analysis of PD with cognitive dysfunction group and PD without cognitive dysfunction group showed that TC and LDL-C of PD with cognitive dysfunction were significantly lower than without cognitive dysfunction(p < 0.05).After binary logistic regression analysis,low level TC was an independent risk factor for cognitive dysfunction in patients with Parkinson's disease(p < 0.05).;(2)The general data and lipid profile analysis of PD with anxiety group and PD without anxiety group showed that the difference in diabetes history,TC,TG and without anxiety group in Parkinson's disease group was statistically significant(p < 0.05).After binary logistic regression analysis,TC and TG were not independent risk factors for anxiety in patients with Parkinson's disease(p < 0.05).(3)The general data and lipid profile analysis of PD with depression group and PD without depression group showed that TC and LDL-C in PD with cognitive dysfunction group were significantly lower than without cognitive dysfunction.The difference was statistically significant(p < 0.05).After binary logistic regression analysis,low levels of TC and LDL-C were independent risk factors for depression in patients with Parkinson's disease(p < 0.05).Conclusions: 1.The incidence of NMS in Parkinson's disease is 95.9%.The highest incidence was autonomic nervous function symptoms,and the frequency of NMS was significantly correlated with age,duration of disease,and severity of illness.2.The overall serum lipids in the Parkinson's disease group were generally lower than those in the healthy control group,TC,LDL-C and ApoA1 was significantly lower than the control group and the difference was statistically significant.3.There is a correlation between serum lipids and NMS,such as: cognitive function,anxiety and depression,and autonomic function in Parkinson's disease.4.Low level of TC is an independent risk factor for cognitive dysfunction in Parkinson's disease.Low levels of TC and LDL-C are independent risk factors for depression in Parkinson's disease.