Study On The Relationship Between Lipids And Cerebral Microbleeds And Their Severity

Objective:To discuss and analyze the influence of lipids and other risk factors on cerebral microbleeds and their severity,and provide relevant theoretical basis for the prevention of Cerebral Microbleeds(CMBs).Methods:A total of 109 patients with lacunar infarction admitted to the Department of Neurology of Affiliated Zhongshan Hospital Dalian University from November 2015 to November 2017 were selected.Magnetic resonance imaging(MRI)was used to select lacunar brain for all patients.Infarction,further detection of susceptibility-weighted imaging(SWI)confirmed CMBs,Collect the clinical data required for the study.All patients were divided into CMBs group and non-CMBs group according to whether there were microbleeds or not.SPSS20.0 software was used for statistical analysis.Count data were analyzed by t-test,(±s)was applied,and measurement data were analyzed by chi-square test.(%)was applied,For factors with significant differences in the above analysis,multivariate logistic regression analysis was performed.p<0.05 was an independent risk factor for CMBs.CMBs were then divided into three grades based on the number of microbleeds.Spearman rank correlation analysis was performed to determine whether independent risk factors were associated with the severity of CMBs is related.Results:1.The results of t-test or chi-square test between the two groups showed that the history of hypertension,uric acid,homocysteine,total cholesterol,triglyceride,and low-density lipoprotein cholesterol had significant differences,p<0.05,age,gender,diabetes,blood glucose,glycated hemoglobin,high-density lipoprotein,apolipoprotein A,apolipoprotein B,apolipoprotein A/apolipoprotein B,lipoprotein A had no significant difference,p>0.05.2.Logistic regression analysis of the differences between the two groups showed that total cholesterol,low-density lipoprotein cholesterol,and hypertension were independent risk factors for CMBs.Uric acid,homocysteine,and triglyceride were not statistically significant.3.Comparison of CMBs between groups,according to the number of microbleeds CMBs group patients were divided into 3 levels,the application of Spearman rank correlation analysis showed that low-density lipoprotein cholesterol was negatively correlated with the number of CMBs,p<0.05,r_s=-0.364,That is,the lower the level of low-density lipoprotein cholesterol,the greater the number of CMBs,which is statistically significant.There is no significant correlation between the total cholesterol and the severity of CMBs,P>0.05.conclusion:1.Total cholesterol,low density lipoprotein cholesterol is an independent risk factor for CMBs.2.Low-density lipoprotein cholesterol and the number of CMBs was negatively correlated.3.Hypertension is an independent risk factor for CMBs.