Association Of The TASK-1 Gene Polymorphism With Severe Obstructive Sleep Apnea

Objective:To explore the mechanism of obstructive sleep apnea via assess the association between the human TASK-1 gene and severe OSA.Method:A total of 164patients with severe OSA and 171 patients without OSA were recruited from the hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region China from April to December 2016.Two single nucleotide polymorphisms(rs1275988 and rs2586886)in TASK-1 gene were selected and genotyped by KASP genotyping system.Result:There were no significant differences in the genotype distributions,allele frequencies,recessive and dominant model of two selected SNPs between severe and non-OSA group in the total population(P>0.05).However,in patients with blood potassium<3.95mmol/L,the distribution of rs1275988 alleles and recessive model(GG+GA vs AA)showed significant differences between severe and non-OSA group(P=0.034 and P=0.038).The distribution of rs2586886 alleles and dominant model(AA+GA vs GA)showed significant differences between severe and non-OSA group(P=0.012 and P=0.035).The Multiple logistic regression analysis showed that the GG genotype was a risk factor for OSA patients with blood potassium<3.95mmol/L,the odds ratio for rs1275988 was 7.845(95%CI:1.710-36.0;P=0.008)and 8.849(95%CI:1.816-43.117;P=0.007)for rs2586886.The Multiple logistic regression analysis showed that the GG genotype was a risk factor for OSA patients with BMI?28kg/m~2,The odds ratio for rs1275988 was 3.662(95%CI:1.069-12.547;P=0.039)and 3.706(95%CI:1.071-12.818;P=0.039)for rs2586886.Conclusion:Both GG genotype of rs1275988 and rs2586886 in TASK-1 gene may play as potential risk factors in OSA patients with blood potassium<3.95mmol/L and BMI?28kg/m~2.Serum potassium levels above 3.95mmol/L in patients with TASK-1 GG genotype may be more conducive to reducing the incidence of OSA.