Correlation Analysis Of Pregnancy Outcomes In Assisted Reproductive Technology In Elderly Infertile Women

Objective:To study the characteristics of different pregnancy outcomes of elderly non-pregnant women treated with ART,and to analyze the related influencing factors,and to actively explore the evaluation value of AMH and FSH in ovarian reserve function.Methods:The data of elderly infertile women treated with ICSI or IVF-ET in the Reproductive Center of the first affiliated Hospital of Xinjiang Medical University from January 2016 to February 2018 were analyzed retrospectively.Clinical pregnancy was divided into two groups.The influencing factors of assisted reproductive technology pregnancy outcome of elderly infertile women were traced back by single and multivariate analysis.According to the difference of AMH and FSH levels,they were divided into two groups:group A(AMH?1.1ng/ml,FSH?10IU/L),B group(AMH?1.1ng/ml,FSH>10IU/L),C group(AMH <1.1ng/ml,FSH?10IU/L),D group(AMH <1.1ng/ml,FSH >10IU/L).To evaluate the prognostic value of AMH and FSH levels in elderly infertile women.Results:A total of 420 patients were included,including 150 cases in clinical pregnancy group and270 cases in non-clinical pregnancy group.There were statistical differences in female age,AMH level,FSH level,number of eggs obtained and(Gn)use time between the two groups(P < 0.05).According to the results of the above studies,the levels of AMH and FSH were related factors of clinical pregnancy outcome.According to the difference of AMH and FSH hormone levels,they were further divided into subgroup A(n = 132,),B group,n = 61,),C group,n = 68).Group D(159 cases).The results showed that the patients in group A were of age.The number of basic AFC in group A was significantly higher than that in group C,and the number of eggs per day in group A was significantly higher than that in group C,and the number of transferable embryos in group A was more than that in group C.the number of eggs obtained in group B was more than that in group C,and the number of eggs per day in group B was more than that in group C.The clinical pregnancy rate was only different between group D and the other three groups,but therewas no difference among the other groups.In addition,the level of LH in the group with poor ovarian function was slightly higher than that in the group with good ovarian function,and the above differences were statistically significant.Conclusion:The age of women,the level of AMH,the level of FSH,the number of eggs obtained,and the use time of gonadotropin(Gn)were the related factors of pregnancy after ART treatment in elderly infertile patients.Compared with the poor ovarian functional reserve between AMH and FSH or poor differential response ovarian function reserve,the pregnancy prognosis of elderly pregnant women with AMH and FSH consistent response ovarian function reserve is obviously superior to that of AMH and FSH consistent response ovarian function reserve.When there was a difference in ovarian function between AMH and FSH,AMH was higher than FSH,in evaluating ovarian reserve function and pregnancy prognosis,but could not predict embryo quality and direct pregnancy outcome.To a certain extent,it can guide the clinical development of individualized treatment for elderly infertile women.