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Preliminary Study On Chronobiology Of Aortic Dissection

Posted on:2020-09-12Degree:MasterType:Thesis
Country:ChinaCandidate:X ZhaoFull Text:PDF
GTID:2404330572973464Subject:Internal medicine
Abstract/Summary:PDF Full Text Request
Objective: This study investigated the temporal characteristics of single-central aortic dissection and its relationship with the lunar phase in Xinjiang,China.To observe the obvious concentration trend of aortic dissection,and to explore the relationship between the lunar phase and the incidence of aortic dissection.Methods: This study retrospectively analyzed the clinical data of 734 patients who were diagnosed and diagnosed as aortic dissection in the First Affiliated Hospital of Xinjiang Medical University from January2009 to August 2015.The patient’s medical records and accurate onset time were recorded in detail.The patients were in the phase of the lunar phase and the near-far location during the onset of the disease,and analyzed the incidence of aortic dissection at different times of daily,weekly,monthly,and seasonal.Results: The mean age of patients was50.43±11.93 years old,and 622 patients(84.7%)under 65 years of age.Compared with patients with type A aortic dissection,patients with type A aortic dissection were younger(mean age 48.83±12.16,P< 0.05),males were more frequent than females(83.7%).There was no statistical difference in gender differences between the different dissection types(P>0.05),61% of patients had hypertension,and hypertensive patients were more susceptible to type B aorta.In the AD dissection(P<0.01),hypertension is a risk factor for type B dissection compared with type A dissection.The risk of type B dissection in hypertensive patients is 1.875 times that of type A.Only 1% of patients had diabetes,0.8%had coronary heart disease,36.6% had a history of drinking,51.9% had a history of smoking,and patients with a history of smoking were more susceptible to type B aortic dissection(P<0.05).In the daily time distribution,the onset time of patients with type A and B aortic dissection was different,and the difference was statistically significant at1:00-4:00,9:00-12:00,13:00-16:00.There are more cases of type B patients than those of type A at 21:00-24:00,and there are more cases of type A in the period from 5:00-8:00 and17:00-20:00 than to type B.The difference in the number of patients with type A in different time periods was statistically significant,with the highest number of casesoccurring from 17:00 to 20:00.In the weekly time distribution,there was no statistical difference in the onset time of the different types of dissection patients during the week(P>0.05).There was no statistical difference in the monthly distribution of the patients in the monthly and seasonal distribution(P >0.05),patients with dissection were more common in winter(P<0.0001).When comparing between different types,patients with type B dissection were more likely to have winter(P=0.001),and there was no difference in seasonal distribution between patients with type A dissection(PP>0.05).In the distribution of the Luner Phase,the patients with dissection occurred in the First quarter and the full moon period,and the difference was statistically significant(P<0.05).No statistical significance was found when comparing the different types of dissection(P>0.05).When the incidence was analyzed in the perigee and apogee,the number of patients with aortic dissection in the perigee was more than the apogee,and the difference was statistically significant.The number of cases was compared:(α=0.05,P=0.020).When analyzed in different types of aortic dissection,the number of A-type aortic dissections in the perigee was more than the apogee,and the difference was statistically significant(α=0.05,P=0.002),there was no significant difference in the incidence of type B aortic dissection between the near and the apogee(P>0.05).Conclusion: The incidence of aortic dissection shows a seasonal pattern and a phase pattern.It may be beneficial to prevent protective aortic dissection in the high-intensity season and phase.
Keywords/Search Tags:Aortic dissection, Time mode, Seasonal mode, Lunar phase, Earth-Moon Cycle
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