The Experimental Research On The Effect Of Kidney Clearing Agent On The Mice With Chronic Urticaria Based On The Theory Of Temperature Discuse

Objective: chronic urticaria is composed of a variety of skin allergic disease caused by pathogenic agents,it happens in the spring,according to its clinical symptoms and the onset time,belongs to the category of science of seasonal febrile diseases "warm spring",the spring temperature belongs to epidemic febrile diseases temperature disease,disease mainly in the heat.The onset of spring temperature is more closely related to the deficiency of Yin essence and deficiency of positive qi.Insufficiency,congenital kidney or other room’s excessive can be caused by kidney essence deficiency,sealed,forming shade essence deficiency constitution,according to "winter not Tibetan essence,spring will be wen" pathogenesis,points out that the essence of kidney deficiency is the intrinsic conditions associated with the onset of spring temperature,kidney essence is insufficient,the spring sun be the spirit of fu,blood diseases with support too,blunt inverse phase for fire,intrinsic wind-cold,meet wind hot outside,and then send to spring temperature,therefore chronic urticaria has spotted faint,camp points,such as heart agitated interference and thirst,cough,sore throat,who points belong to the spring temperature central camp with disease symptoms,used in the treatment of nourishing Yin and heat treatment,so the teacher,according to the Yin heating treatment "kidney clear party",HIS own is liuwei dihuang pill and fructus forsythiae bulk chemical,cutting through the animal experiment model,were observed before and after treatment serum immunoglobulin E(IgE),the variation in content of HIStamine(ihs),interleukin 4(IL-4),cell interferon-gamma(IFN-gamma)expression level,understand the kidney on the clear party the curative effect of treatment of chronic urticaria,thus providing ideas and to study the treatment method of reliable basis.Methods: using randomized controlled methods,50 male mice were randomly divided into blank group,model group,loratadine group,high dose group,qing qing fang low-dose group,respectively to different drug lavage,and detecting HIStamine in mice serum before and after the treatment(ihs),the content of immunoglobulin E(IgE),interleukin 4(IL-4),cell interferon-gamma(IFN-gamma)expression level.Results: compared with model group,fill the qing fang high dose group,qing dynasty low doses of HIStamine(ihs)in the serum,reduce the content of immunoglobulin E(IgE),interleukin 4(IL-4)expression levels(P≤ 0.05)or less.Conclusion: the treatment of the kidney essence deficiency type kidney clear party chronic urticaria can effectively adjust the balance of Th1 / Th2 cytokines,by reducing the amount of HIStamine(ihs),immunoglobulin E(IgE)content,inhibition of interleukin 4(IL-4)expression,thus inhibiting urticaria,from the perspective of immunology to explore in the treatment of kidney essence deficiency type kidney clear party provides reference for the mechanism of action of chronic urticaria.