The Optimization Of WB-DWI Sequence And The Clinical Value Of It On Staging For Multiple Myeloma

Objective1.To optimize the imaging parameters of the WB-DWI sequence in order to achieve the optimal subjective and objective indicators on image quality.2.To observe the advantage of WB-DWI sequence in the diagnosis of multiple myeloma,when the optimized sequence was applied on.Subjects and Methods1.In the parameter setting of whole-body diffusion-weighted imaging sequence,the lower b value,higher b value and very high b value were set to 400s/mm2,900s/mm2 and 1400s/mm2 respectively.The image quality with different b value was evaluated by subjective analysis and objective analysis respectively.The b value with optimal subjective and objective indicators was selected as the scanning parameters used for MM.2.The optimized WB-DWI sequence was applied on the scanning of multiple myeloma.48 patients with newly diagnosed and untreated MM were performed whole-body MRI scanning.The scanning sequences were divided into two groups.One group was the optimized WB-DWIsequence,which was used as the experimental group.The other group was conventional imaging sequence,which was served as a control group.After scanning,the differences in sensitivity and accuracy of diagnosis of myeloma lesions between the two groups were compared,thus reflecting the advantages of WB-DWI in diagnosis of multiple myeloma.Results1.The tumor with very high b value was contrasted well,but with the worst signal-to-noise ratio.Images with lower b value got the best signal-to-noise ratio,however,they were not sensitive to the movement of water molecules.Considering subjective and objective indicators comprehensively,it was reasonable to select a higher b value(900s/mm2)as the b value in the WB-DWI scanning of multiple myeloma.2.The sensitivity of diffusion-weighted imaging sequence to myeloma lesions was better than that of conventional T1WI and T2STIR protocal(P<0.001).Diffusion-weighted imaging could detect more tumor loads,and the accuracy rate of diffusion-weighted imaging to myeloma staging was higher than that of conventional imaging sequences.Conclusion1.The selection of b value on the WB-DWI sequence had a significant impact on the imaging quality.By optimizing it,we choose the higher b value(900s/mm2)as the optimal imaging parameter.2.Diffusion-weighted imaging was better than conventional MRI protocal in the sensitivity and accuracy of diagnosis of multiple myeloma,so it is worthy of extensive promotion.